Associations of arterial tissue lipids with coronary heart disease risk factors in young people
| Autor: | Henry C. McGill, Edward E. Herderick, Jack P. Strong, Dana Troxclair, Gray T. Malcom, Richard E. Tracy, C. Alex McMahan |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Coronary Disease Young Adult chemistry.chemical_compound Left coronary artery Risk Factors medicine.artery Internal medicine medicine Humans Aorta Abdominal cardiovascular diseases Risk factor Vascular disease business.industry Cholesterol Abdominal aorta Atherosclerosis medicine.disease Coronary Vessels Coronary heart disease medicine.anatomical_structure chemistry Hyperglycemia Hypertension Circulatory system Cardiology Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Blood vessel |
| Zdroj: | Atherosclerosis. 203:515-521 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2008.07.002 |
| Popis: | Objective To examine the associations of the coronary heart disease (CHD) risk factors with lipid composition of arterial tissue in 397 autopsied subjects 15–34 years of age from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and results We measured esterified cholesterol, free cholesterol, and phospholipid in the left circumflex coronary artery and two segments of the abdominal aorta, one of which is more susceptible to advanced atherosclerosis than the other, and also measured the major CHD risk factors. Non-HDL cholesterol concentration was positively associated, and HDL cholesterol concentration was negatively associated, with tissue lipids in the left circumflex coronary artery and the abdominal aorta. Hypertension was positively associated with tissue lipids in both arteries. Hyperglycemia was associated with tissue lipids in the left circumflex coronary artery and smoking with lipids in the abdominal aorta. PDAY risk scores summarize the effects of the CHD risk factors on advanced atherosclerosis. These risk scores, computed from the mutable risk factors, were associated with tissue lipids in the left circumflex coronary artery and both segments of the abdominal aorta. Conclusions The CHD risk factors are associated with lipids in arterial tissue just as they are associated with gross and microscopic lesions. These results support the proposal that early control of risk factors is likely to prevent or delay progression of atherosclerosis and prevent or delay the onset of CHD. |
| Databáze: | OpenAIRE |
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