Tumor to Tumor Metastasis from Adenocarcinoma Not Otherwise Specified of the Parotid Gland to Uterine Leiomyoma: Presentation of a Unique Case
| Autor: | Anastasios Grivas, Dimitrios C. Papatheodorou, Lubna Khaldi, Nektarios Koufopoulos, Alexandros Psarris |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Uterus 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Medicine tumor to tumor metastasis adenocarcinoma not otherwise specified Lymph node Uterine leiomyoma uterine leiomyoma business.industry Not Otherwise Specified General Engineering distant metastasis medicine.disease Parotid gland medicine.anatomical_structure Leiomyoma Oncology Obstetrics/Gynecology Adenocarcinoma Salivary Gland Adenocarcinoma parotid gland business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Salivary gland adenocarcinoma not otherwise specified (NOS) is a malignant epithelial tumor composed of ductal/glandular structures with or without cystic formation. Histologically it is classified as high grade with relevant biological behavior. Although both minor and major glands may be involved, the majority (60%) implicate the parotid gland. Location, regional lymph node status, and histological grade are some of the factors that predict the progress of the disease and the development of metastases. Long follow-up is considered the standard option as distant metastases (DM) may occur despite regional control. Primary sites of DM, besides lymph nodes, include bone, lung, and liver. Herein we report a unique case of a 68-year-old female with a previous history of high-grade adenocarcinoma NOS of her right parotid gland. On her biannual follow-up examination, MRI revealed an abnormal increase in the size of a known uterine leiomyoma of the posterior uterine wall. Positron emission tomography-CT (PET-CT) showed increased uptake in the uterus and lungs. On frozen section, adenocarcinoma was found at the center of the leiomyoma. Histological and immunohistochemical findings were consistent with secondary involvement by the salivary gland adenocarcinoma NOS. Treatment consisted of cyclophosphamide, adriamycin, and cisplatin with poor outcome. The patient was lost to follow-up. Review of the literature indicates that no similar case has been reported in the English literature. |
| Databáze: | OpenAIRE |
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