Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
| Autor: | Dina Ioffe, Efrat Dotan, Pooja Phull |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis business.industry medicine.medical_treatment Treatment options Guideline Review Evidence based review chemotherapy targeted therapy Molecular heterogeneity Optimal management Targeted therapy Internal medicine Epidemiology detectable mutations medicine molecular business cholangiocarcinoma |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| Popis: | Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas. |
| Databáze: | OpenAIRE |
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