Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias
| Autor: | Abdulgabar Salama |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Agglutination
medicine.medical_specialty Immune haemolysis IgG DAT business.industry C3d DAT Review Article Hematology Bidirectional communication Negative DAT Coombs-negative Serology Immune system Autoimmune haemolytic anaemia Immunology Haemolytic anaemias Autoimmune haemolytic anaemias medicine Immunology and Allergy Positive DAT AIHA Intensive care medicine business |
| Zdroj: | Transfusion Medicine and Hemotherapy |
| ISSN: | 1660-3818 1660-3796 |
| DOI: | 10.1159/000438960 |
| Popis: | Autoimmune haemolytic anaemias (AIHAs) are well-characterized disorders. They can be differentiated from one another and from other non-immune haemolytic anaemias by clinical, laboratory and serological testing. However, several misleading clinical presentations and/or serological findings may result in misinterpretation, delay and/or misdiagnosis. Such failures are avoidable by adequate clinical and serological experience of the responsible physicians and serologists or, at least, by an optimised bidirectional communication. As long as this has not been achieved, unpleasant failures are to be expected. A true diagnosis of AIHA can neither be verified by clinical nor serological findings alone. Thus, a collective clinical and serological picture remains obligatory for fulfilling the criteria of optimal diagnosis and therapy. Ultimately, the majority of pioneer scientific and practical work in this field stems from scientists who were simultaneously involved in both the clinic and serology. |
| Databáze: | OpenAIRE |
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