A previously unknown way of heme detoxification in the digestive tract of cats
| Autor: | Yuri P. Tsentalovich, Vadim V. Yanshole, Petr S. Sherin, O. I. Sinitsyna, Sergey L. Veber, S. I. Baiborodin, Alexandr B. Duzhak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
ADSORPTION 02 engineering and technology Matrix (biology) Biochemistry TOXICITY chemistry.chemical_compound Feces Heme Multidisciplinary CATS Gastric Juice Hemozoin IRON MIDGUT Gastroenterology 021001 nanoscience & nanotechnology Chemical biology Multidisciplinary Sciences medicine.anatomical_structure TARGET Inactivation Metabolic Medicine Science & Technology - Other Topics 0210 nano-technology BONE Science Article Excretion 03 medical and health sciences Detoxification medicine Animals Science & Technology RED Animal Feed In vitro Small intestine Diet Gastrointestinal Tract 030104 developmental biology CARBONATED HYDROXYAPATITE Durapatite chemistry Cats Nanoparticles HEMOZOIN |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone of this process is the encapsulation of heme into carbonated hydroxyapatite nanoparticles, followed by their excretion with faeces. This way of heme neutralization resembles the formation of insoluble heme-containing particles in the digestive tracts of other hematophagous species (for example, the formation of insoluble hemozoin crystals in malaria-causing Plasmodium parasites). Our findings suggest that the encapsulation of heme molecules into a hydroxyapatite matrix occurs during the transition from the acidic gastric juice to the small intestine with neutral conditions. The formation of these particles and their efficiency to include heme depends on the bone content in a cat’s diet. In vitro experiments with heme-hydroxyapatite nanoparticles confirm the proposed scenario. |
| Databáze: | OpenAIRE |
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