Susceptibility source separation from gradient echo data using magnitude decay modeling

Autor: Alexey V. Dimov, Thanh D. Nguyen, Kelly M. Gillen, Melanie Marcille, Pascal Spincemaille, David Pitt, Susan A. Gauthier, Yi Wang
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neuroimaging. 32:852-859
ISSN: 1552-6569
1051-2284
DOI: 10.1111/jon.13014
Popis: The objective is to demonstrate feasibility of separating magnetic sources in quantitative susceptibility mapping (QSM) by incorporating magnitude decay ratesmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:annotation$R_2^{\rm{*}}$/mml:annotation/mml:semantics/mml:mathin gradient echo (GRE) MRI.Magnetic susceptibility source separation was developed usingmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:annotation$R_2^{\rm{*}}$/mml:annotation/mml:semantics/mml:mathand compared with a prior method usingmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:mrowmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo'/mml:mo/mml:msubsupmml:mo=/mml:momml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:mo-/mml:momml:msubmml:miR/mml:mimml:mn2/mml:mn/mml:msub/mml:mrowmml:annotation${R^{\prime}_2} = R_2^* - {R_2}$/mml:annotation/mml:semantics/mml:maththat required an additional sequence to measure the transverse relaxation rate Rsub2/sub. Both susceptibility separation methods were compared in multiple sclerosis (MS) patients (n = 17). Susceptibility values of negative sources estimated withmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:annotation$R_2^{\rm{*}}$/mml:annotation/mml:semantics/mml:math-based source separation in a set of enhancing MS lesions (n = 44) were correlated against longitudinal myelin water fraction (MWF) changes.In in vivo data, linear regression of the estimatedmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msupmml:miχ/mml:mimml:mo+/mml:mo/mml:msupmml:annotation${\chi}^{+}$/mml:annotation/mml:semantics/mml:mathandmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msupmml:miχ/mml:mimml:mo-/mml:mo/mml:msupmml:annotation${\chi}^{-}$/mml:annotation/mml:semantics/mml:mathsusceptibility values between themml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:annotation$R_2^*$/mml:annotation/mml:semantics/mml:math- and themml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo'/mml:mo/mml:msubsupmml:annotation${R^{\prime}_2}$/mml:annotation/mml:semantics/mml:math-based separation methods performed across 182 segmented lesions revealed correlation coefficient r = .96 and slope close .99. Correlation analysis in enhancing lesions revealed a significant positive association between themml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msupmml:miχ/mml:mimml:mo-/mml:mo/mml:msupmml:annotation${\chi}^{-}$/mml:annotation/mml:semantics/mml:mathincrease at 1-year post-onset relative to 0 year and the MWF increase at 1 year relative to 0 year (β = -0.144, 95% confidence interval: [-0.199, -0.1], p = .0008) and good agreement betweenmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo'/mml:mo/mml:msubsupmml:annotation${R^{\prime}_2}$/mml:annotation/mml:semantics/mml:mathandmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msubsupmml:miR/mml:mimml:mn2/mml:mnmml:mo∗/mml:mo/mml:msubsupmml:annotation$R_2^*$/mml:annotation/mml:semantics/mml:mathmethods (r = .79, slope = .95).Separation of magnetic sources based solely on GRE complex data is feasible by combining magnitude decay rate modeling and phase-based QSM andmml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"mml:semanticsmml:msupmml:miχ/mml:mimml:mo-/mml:mo/mml:msupmml:annotation${\chi}^{-}$/mml:annotation/mml:semantics/mml:mathchange may serve as a biomarker for myelin recovery or damage in acute MS lesions.
Databáze: OpenAIRE
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