Inorganic phosphate uptake in unicellular eukaryotes
| Autor: | André L.A. Dos-Santos, Claudia F. Dick, José Roberto Meyer-Fernandes |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Trypanosoma rangeli
Trypanosoma cruzi Microorganism Plasmodium falciparum Saccharomyces cerevisiae Biophysics Biochemistry Phosphates Microbiology Neurospora crassa parasitic diseases Homeostasis Phosphate Transport Proteins Leishmania infantum Molecular Biology Gene biology Cell Membrane biology.organism_classification Eukaryotic Cells Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:2123-2127 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/j.bbagen.2014.03.014 |
| Popis: | Background Inorganic phosphate (Pi) is an essential nutrient for all organisms. The route of Pi utilization begins with Pi transport across the plasma membrane. Scope of review Here, we analyzed the gene sequences and compared the biochemical profiles, including kinetic and modulator parameters, of Pi transporters in unicellular eukaryotes. The objective of this review is to evaluate the recent findings regarding Pi uptake mechanisms in microorganisms, such as the fungi Neurospora crassa and Saccharomyces cerevisiae and the parasite protozoans Trypanosoma cruzi, Trypanosoma rangeli, Leishmania infantum and Plasmodium falciparum. Major conclusion Pi uptake is the key step of Pi homeostasis and in the subsequent signaling event in eukaryotic microorganisms. General significance Biochemical and structural studies are important for clarifying mechanisms of Pi homeostasis, as well as Pi sensor and downstream pathways, and raise possibilities for future studies in this field. |
| Databáze: | OpenAIRE |
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