Factors Associated with Hyperhomocysteinemia After Renal Transplantation

Autor:	Milan Radovic, Dusan Babić, Ljubica Dukanović, D Radivojevic, Dusan Mirković, Sanja Simić-Ogrizović, Visnja Lezaic
Rok vydání:	2006
Předmět:	Adult Male Nephrology medicine.medical_specialty Hyperhomocysteinemia medicine.medical_treatment Renal function Critical Care and Intensive Care Medicine Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Kidney transplantation Dialysis Kidney Creatinine business.industry Incidence General Medicine medicine.disease Kidney Transplantation Transplantation Endocrinology medicine.anatomical_structure chemistry Female business
Zdroj:	Renal Failure. 28:57-62
ISSN:	1525-6049 0886-022X
DOI:	10.1080/08860220500461260
Popis:	Recent studies show that clinically stable renal transplant recipients have an increased prevalence of hyperhomocysteinemia (hyperHcy), but the mechanism of this disorder has not yet been elucidated. The aim of the present study was to evaluate the factors associated with hyperHcy after a successful renal transplantation. In 106 stable renal transplant recipients, total serum Hcy level (tHcy), folate, total protein, serum creatinine concentration, creatinine clearance, lipid status, body weight (BW), body mass index (BMI), and body fat (BF) were determined. The mean doses of cyclosporine, prednisolone, and azathioprine (mg/kg/day) were recorded. The mean serum tHcy level was significantly higher in renal transplant patients than in healthy controls (22.02 +/- 8.02 versus 13.0 +/- 3.3 micromol/ L; p0.001), and the incidence of patients with hyperHcy was 82%. Comparison of the group of 20 patients with tHcy level15 micromol/L and the group of 86 patients with tHcy level15 micromol/L revealed that the latter was significantly older, heavier, had been longer on dialysis before renal transplantation, and had older donors and poorer renal graft function. Significant correlation was found between tHcy level and recipient age, dialysis duration, BW, creatinine clearance, serum creatinine, and folate concentration. However, multivariate analysis indicated that creatinine clearance (p = 0.025) and BW (p = 0.03) were the only determinants of elevated total Hcy level in renal transplant recipients. HyperHcy persists after successful kidney transplantation in the majority of renal transplant recipients, and its appearance is primarily associated with creatinine clearance and body weight.
Databáze:	OpenAIRE
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