Advanced stage mucinous epithelial ovarian cancer: the Hellenic Cooperative Oncology Group experience
Autor: | Dimosthenis Skarlos, E. Efstathiou, H. P. Kalofonos, Dimitrios Farmakis, George Fountzilas, Evangelos Briasoulis, Emmanouel Salamalekis, Meletios A. Dimopoulos, Gerasimos Aravantinos, Theofanis Economopoulos, Dimitrios Pectasides |
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Rok vydání: | 2004 |
Předmět: |
Oncology
Adult Cisplatin/administration & dosage/*therapeutic use medicine.medical_specialty Carboplatin/administration & dosage/*therapeutic use Cyclophosphamide Paclitaxel medicine.medical_treatment Context (language use) Ovarian Neoplasms/*drug therapy/pathology/surgery Carboplatin chemistry.chemical_compound Paclitaxel/administration & dosage Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Stage (cooking) Survival rate Aged Neoplasm Staging Retrospective Studies Ovarian Neoplasms Chemotherapy business.industry Obstetrics and Gynecology Middle Aged medicine.disease Adenocarcinoma Mucinous Combined Modality Therapy Survival Rate Treatment Outcome chemistry Adenocarcinoma Mucinous/*drug therapy/pathology/surgery Adenocarcinoma Female Cisplatin business Epirubicin medicine.drug |
Zdroj: | Gynecologic oncology. 97(2) |
ISSN: | 0090-8258 |
Popis: | Purpose. Ovarian clear-cell carcinomas (OCCC) are known to be possibly resistant to platinum-based chemotherapy and to have a poorer prognosis with respect to other subtypes of epithelial ovarian cancer (EOC). This study was undertaken to compare response and survival to platinum-based chemotherapy between patients with advanced stage III and IV OCCC and serous EOC (sEOC). Patients and methods. A retrospective analysis was performed in patients with advanced stage of OCCC treated with first-line platinum-based chemotherapy in the context of several study protocols of the Hellenic Cooperative Oncology Group (HeCOG) between 1/2/1987 and 31/10/2003. The outcome was compared to that of patients with sEOC treated according to the same protocols during the same study period. Results. One hundred and five patients (35 stage III and IV OCCC, 70 stage III and IV sEOC) treated with platinum-based chemotherapy were analyzed. The overall response rate for OCCC was 45% (complete response 25%) (95% CI, 23.1% to 68.5%) and 81% (complete response 46%) (95% CI, 67.4% to 91.1%) for sEOC. The overall response rate was significantly higher for sEOC ( P = 0.008). In the subgroup of stage III patients, the rate of complete responders was higher among sEOC patients ( P = 0.023). After a median follow-up of 61.1 months, median survival and time to tumor progression were not significantly different between the two groups (25.1 months [95% CI 11.7 to 38.5 months] versus 49.1 months [95% CI 36.5 to 61.6 months], P = 0.141, 12.0 months [95% CI 6.5 to 17.3 months] versus 18.0 months [95% CI 14.7 to 21.6 months], P = 0.384, respectively). Conclusion. Patients with OCCC have significantly lower response to platinum-based first-line chemotherapy compared to patients with sEOC. This low response to platinum-based chemotherapy was not translated in significantly shorter survival. The current study outcomes are provocative and suggest that a new strategy for chemotherapy in OCCC should be adopted, possibly one that focuses on new agents without cross-resistance to platinum agents. |
Databáze: | OpenAIRE |
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