Associations between hsa-miR-603 polymorphism, lifestyle-related factors and colorectal cancer risk
| Autor: | Zhenyu Zhang, Jian-feng Guo, Kun Chen, Xiang-jue Sun, Mingjuan Jin, Yingying Mao, Fen-juan Wang, Long-fang Jiang, Fangyuan Jing, Ye Ding |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology China Cancer Research medicine.medical_specialty Genotype Colorectal cancer Single-nucleotide polymorphism Polymorphism Single Nucleotide Colorectal tumorigenesis Internal medicine Genetics Humans Medicine Life Style Related factors business.industry General Medicine Odds ratio Middle Aged medicine.disease Confidence interval MicroRNAs Case-Control Studies Female Colorectal Neoplasms business |
| Zdroj: | Cancer Biomarkers. 14:225-231 |
| ISSN: | 1875-8592 1574-0153 |
| DOI: | 10.3233/cbm-140395 |
| Popis: | Background Accumulated studies have suggested that single nucleotide polymorphisms (SNPs) in microRNAs are associated with risk of colorectal cancer (CRC). Objective We tested our hypothesis that rs11014002 in hsa-miR-603 may be associated with CRC risk with a crosstalk of life-related factors. Methods We conducted a case-control study which included 102 CRC patients and 204 matched cancer-free controls in Xiaoshan County. Results We observed that subjects with rs11014002 CT/TT genotype had an increased susceptibility for CRC (CT vs. CC: odds ratio (OR)=2.352, 95% confidence interval (CI): 1.142-4.840, P=0.020; CT+TT vs. CC: OR=2.031, 95% CI: 1.063-3.883, P=0.032). After stratification by lifestyle-related factors, similar results were found among nonsmokers (CT vs. CC: OR=2.753, 95% CI: 1.085-6.983, P=0.033; CT+TT vs. CC: OR=2.971, 95% CI: 1.188-7.435, P=0.020) and non-alcohol drinkers (CT+TT vs. CC: OR=3.279, 95% CI: 1.071-10.033, P=0.037). Conclusions Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility. |
| Databáze: | OpenAIRE |
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