Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model
| Autor: | Waldemar S. Costa, José Aurelino Damasceno-Ferreira, Gustavo R. Bechara, Marco A. Pereira-Sampaio, Leonardo Albuquerque dos Santos Abreu, Diogo Benchimol de Souza, Francisco J.B. Sampaio |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty RD1-811 Swine medicine.medical_treatment Kidney Glomerulus 030232 urology & nephrology Ischemia urologic and male genital diseases Nephrectomy 03 medical and health sciences Renal Artery 0302 clinical medicine Models medicine.artery Internal medicine medicine Animals Warm Ischemia Renal artery Kidney Renal ischemia business.industry urogenital system Animal Organ Size medicine.disease Warm ischemia Clamping Surgery Disease Models Animal medicine.anatomical_structure 030220 oncology & carcinogenesis Cardiology Laparoscopy business |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 31, Issue: 11, Pages: 753-758, Published: NOV 2016 Acta Cirúrgica Brasileira v.31 n.11 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 31, Iss 11, Pp 753-758 (2016) |
| Popis: | PURPOSE: To evaluate the glomerular loss after arteriovenous or arterial warm ischemia in a swine model. METHODS: Twenty four pigs were divided into Group Sham (submitted to all surgical steps except the renal ischemia), Group AV (submitted to 30 minutes of warm ischemia by arteriovenous clamping of left kidney vessels), and Group A (submitted to 30 minutes of ischemia by arterial clamping). Right kidneys were used as controls. Weigh, volume, cortical volume, glomerular volumetric density (Vv[Glom]), volume-weighted glomerular volume (VWGV), and the total number of glomeruli were measured for each organ. RESULTS: Group AV showed a 24.5% reduction in its left kidney Vv[Glom] and a 25.4% reduction in the VWGV, when compared to the right kidney. Reductions were also observed when compared to kidneys of sham group. There was a reduction of 19.2% in the total number of glomeruli in AV kidneys. No difference was observed in any parameters analyzed on the left kidneys from group A. CONCLUSIONS: Renal warm ischemia of 30 minutes by arterial clamping did not caused significant glomerular damage, but arteriovenous clamping caused significant glomerular loss in a swine model. Clamping only the renal artery should be considered to minimize renal injury after partial nephrectomies. |
| Databáze: | OpenAIRE |
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