Selenium lethality: role of glutathione and metallothionein
| Autor: | Hamid R. Rasekh, Rosonald R. Bell, Ronaldo A. Potmis, Johnnie L. Early, Vani K. Nonavinakere |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Toxicology Kidney Rats Sprague-Dawley chemistry.chemical_compound Selenium Internal medicine medicine Metallothionein Animals Saline Chemistry Liver and kidney Maleates Kidney metabolism General Medicine Glutathione Propylene Glycol Rats Endocrinology Liver metabolism Biochemistry Liver Propylene Glycols Toxicity Injections Intraperitoneal |
| Zdroj: | Toxicology letters. 66(3) |
| ISSN: | 0378-4274 |
| Popis: | Male Sprague-Dawley rats (200-300 g) were pretreated (i.p.) with diethylmaleate (DEM; 3.1 mmol/kg) or propylene glycol (PG). After 1 h, three PG and three DEM groups received saline or sodium selenite (Se: 0.8 or 1.6 mg/kg) i.p. Eighty to one hundred percent mortality occurred within 3 h after Se in DEM-pretreated groups. Except for one PG and one DEM group, which were sacrificed after 1 h, the remaining groups received saline or Se (1.6 mg/kg) 25 h after pretreatment. No mortality occurred within 3 h after Se. Liver and kidney GSH decreased at 1 h, while liver MT increased at 28 h. The changes are related to Se-induced lethality. |
| Databáze: | OpenAIRE |
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