Antiphospholipid antibodies in systemic lupus erythematosus: Clinical and laboratory associations in 111 patients
| Autor: | T Chivers, Leslie Schrieber, M G Cohen, Kenneth Michael Pollard, Y. Wang, L. J. Furphy, J. Webb |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cardiolipins Immunology Disease Antibodies Rheumatology Coombs test Central Nervous System Diseases Pregnancy immune system diseases Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Fetal Death neoplasms Phospholipids Aged Lupus erythematosus medicine.diagnostic_test biology business.industry Thrombosis Syndrome Middle Aged medicine.disease Thrombocytopenia Pregnancy Complications Coombs Test biology.protein Female Anticardiolipin antibodies Antibody business |
| Zdroj: | Rheumatology International. 10:75-80 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/bf02274787 |
| Popis: | An enzyme linked immunosorbent assay (ELISA) was used to evaluate the prevalence and disease associations of antibodies to a range of negatively charged phospholipids in 111 patients with systemic lupus erythematosus (SLE). The frequency of one or more isotypes of different antiphospholipid antibodies (APLs) was similar (range 33%-45%). When individual isotypes were considered alone there was considerable variation (range 5%-32%). There were significant associations between thrombosis, thrombocytopenia, and central nervous system (CNS) disease but not abortion with elevated APL. Strong associations were found between raised anti-ds-DNA (Farr assay) and a positive direct Coomb's test with raised APL. Thus, APLs are common in SLE and are associated with discrete clinical and laboratory features. However, detection of antibodies to a range of negatively charged phospholipids added little clinically useful information to that obtained by measuring anticardiolipin antibody (ACL) alone. We cannot recommend the use of APLs other than ACL for routine testing. |
| Databáze: | OpenAIRE |
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