Endotoxemia decreases matching of regional blood flow and O(2) delivery to O(2) uptake in the porcine left ventricle
| Autor: | Thomas W. Binsl, A. B. Johan Groeneveld, Johannes H. G. M. van Beek, Frans J. J. de Kanter, David J. C. Alders |
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| Přispěvatelé: | Physiology, Intensive care medicine, Human genetics, NCA - Photonics & Life Cell Imaging, ICaR - Ischemia and repair, Bioinformatics, Neuroscience Campus Amsterdam - Photonics & Life Cell Imaging |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Cardiac output Physiology Swine Sepsis syndrome Hemodynamics Coronary circulation Ventricular Dysfunction Left Oxygen Consumption SDG 3 - Good Health and Well-being Physiology (medical) Coronary Circulation Medicine Animals Lactic Acid Cardiac Output Normal heart business.industry Blood flow Coronary Vessels Endotoxemia Endotoxins Oxygen medicine.anatomical_structure Ventricle Anesthesia Circulatory system Hypotension Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology. Heart and Circulatory Physiology, 300(4), H1459-H1466. American Physiological Society Alders, D J C, Groeneveld, A B J, Binsl, T W, de Kanter, F J & van Beek, J H G M 2011, ' Endotoxemia decreases matching of regional blood flow and O(2) delivery to O(2) uptake in the porcine left ventricle ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1459-H1466 . https://doi.org/10.1152/ajpheart.00287.2010 |
| ISSN: | 0363-6135 |
| DOI: | 10.1152/ajpheart.00287.2010 |
| Popis: | Heterogeneity of regional coronary blood flow is caused in part by heterogeneity in O2 demand in the normal heart. We investigated whether myocardial O2 supply/demand mismatching is associated with the myocardial depression of sepsis. Regional blood flow (microspheres) and O2 uptake ([13C]acetate infusion and analysis of resultant NMR spectra) were measured in about nine contiguous tissue samples from the left ventricle (LV) in each heart. Endotoxemic pigs ( n = 9) showed hypotension at unchanged cardiac output with a fall in LV stroke work and first derivative of LV pressure relative to controls ( n = 4). Global coronary blood flow and O2 delivery were maintained. Lactate accumulated in arterial blood, but net lactate extraction across the coronary bed was unchanged during endotoxemia. When LV O2 uptake based on blood gas versus NMR data were compared, the correlation was 0.73 ( P = 0.007). While stable over time in controls, regional blood flows were strongly redistributed during endotoxin shock, with overall flow heterogeneity unchanged. A stronger redistribution of blood flow with endotoxin was associated with a larger fall in LV function parameters. Moreover, the correlation of regional O2 delivery to uptake fell from r = 0.73 ( P < 0.001) in control to r = 0.18 ( P = 0.25, P = 0.009 vs. control) in endotoxemic hearts. The results suggest a redistribution of LV regional coronary blood flow during endotoxin shock in pigs, with regional O2 delivery mismatched to O2 demand. Mismatching may underlie, at least in part, the myocardial depression of sepsis. |
| Databáze: | OpenAIRE |
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