Combined photodynamic therapy and intravitreal triamcinolone injection for the treatment of choroidal neovascularisation secondary to pathological myopia: a pilot study

Autor: Amy L Wong, David T.L. Liu, Dennis S.C. Lam, Wai-Man Chan, Timothy Y Y Lai
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Refractive error
Triamcinolone acetonide
Visual acuity
genetic structures
Eye disease
Visual Acuity
Triamcinolone Acetonide
polycyclic compounds
Aged
80 and over
education.field_of_study
Middle Aged
Prognosis
Verteporfin
Combined Modality Therapy
Sensory Systems
Choroidal neovascularization
medicine.anatomical_structure
Editorial
Treatment Outcome
Myopia
Degenerative
Female
medicine.symptom
therapeutics
medicine.drug
Adult
medicine.medical_specialty
Population
Injections
Cellular and Molecular Neuroscience
Ophthalmology
medicine
Humans
education
Glucocorticoids
Aged
business.industry
Clinical Science - Extended Report
Macular degeneration
medicine.disease
eye diseases
Choroidal Neovascularization
Surgery
Vitreous Body
Photochemotherapy
Maculopathy
sense organs
Choroid
business
Epidemiologic Methods
Popis: Background: To assess the efficacy and safety of combined intravitreal triamcinolone (IVTA) and photodynamic therapy (PDT) with verteporfin in the treatment of choroidal neovascularisation (CNV) secondary to pathological myopia. Methods: 22 eyes of 22 patients with subfoveal or juxtafoveal CNV due to pathological myopia were prospectively recruited for combined PDT with IVTA. The treatment outcomes at 1 year were compared with those in a control group of 22 eyes that received PDT monotherapy. Results: At 1 year, the logMAR best-corrected visual acuity (BCVA) for the combined PDT with IVTA group changed from 0.62 to 0.61 (p = 0.74), whereas that for the monotherapy group changed from 0.61 to 0.67 (p = 0.33). The mean logMAR BCVA and proportions of patients without losing ⩾3 lines at 1 year were similar between the two groups (p = 0.68 and 0.74, respectively). Subgroup analyses showed that eyes with baseline logMAR BCVA worse than 0.6 (Snellen equivalent 20/80) or CNV with greatest linear dimension ⩾750 μm which received combined therapy had better mean logMAR BCVA at 1 year (p = 0.023 and 0.041, respectively), with a higher proportion of eyes gaining ⩾2 lines of BCVA (p = 0.027 and 0.017, respectively) compared with PDT monotherapy. Conclusions: Combined PDT with IVTA did not seem to result in significantly better visual outcome compared with PDT monotherapy. However, combined therapy might result in better visual outcome in selected patients with worse initial visual acuity or larger myopic CNV. Further studies are warranted to investigate the role of combined PDT with IVTA in the treatment of myopic CNV, especially in patients with worse prognostic factors.
Databáze: OpenAIRE
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