Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth
| Autor: | Oyinkansola Osobamiro, Xuguang Zheng, Michael Chopp, Ben Buller, Mark Katakowski, Thomas J. Rogers, Wayne Shu, Feng Jiang, Yong Lu |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research Stromal cell Injections Intralesional Exosomes Exosome Article Glioma microRNA medicine Animals Humans Expression vector Brain Neoplasms Chemistry Mesenchymal stem cell Gene Transfer Techniques Mesenchymal Stem Cells Genetic Therapy Transfection medicine.disease Rats Inbred F344 Microvesicles Rats Tumor Burden MicroRNAs Oncology Cancer research Neoplasm Transplantation |
| Zdroj: | Cancer Letters. 335:201-204 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2013.02.019 |
| Popis: | Exosomes are 30–150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor. |
| Databáze: | OpenAIRE |
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