TaqIA polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patients
| Autor: | Christian Wolfrum, Gottfried Rudofsky, Maik Brune, Peter P. Nawroth, Julia K. Winkler, Tenagne D. Challa, Annika Woehning, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Nigel Beaton, Eva Roeder, Stella Minkova |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Patient Dropouts Adolescent Diet Reducing Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Weight loss Polymorphism (computer science) Internal medicine Dopamine receptor D2 Weight Loss Genotype medicine Humans Obesity Allele Genotyping Alleles Aged 2. Zero hunger Polymorphism Genetic Nutrition and Dietetics Receptors Dopamine D2 business.industry Age Factors Middle Aged Achievement medicine.disease Weight Reduction Programs Endocrinology Female medicine.symptom business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Nutrition Nutrition; Vol 28 |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/j.nut.2011.12.018 |
| Popis: | Objective The A1 allele of the Taq IA polymorphism in the dopamine D2 receptor gene (rs1800497) has been associated with obesity. However, the effect of the polymorphism on the success in weight loss and/or weight maintenance during weight-loss programs has not been evaluated thus far. Methods The rs1800497 was genotyped in 202 (135 female, 67 male) severely obese individuals with an initial body mass index of 41.7 ± 0.5 kg/m 2 who participated in a weight-loss program consisting of a weight-loss phase with a formula diet (12 wk) and a weight-maintenance phase (40 wk). Measurements were collected at baseline, after the weight-loss phase, and at the end of the weight-maintenance phase at 1 y. Results Genotyping revealed 4 A1A1, 67 A1A2, and 131 A2A2 genotype carriers. Of the 202 subjects in the program, 66.8% completed the program and 33.2% terminated prematurely. Neither the attrition rate ( P = 0.44) nor the overall weight loss was influenced by the different genotypes ( P = 0.96). However, younger A1 + participants (A1A1 and A1A2) had a higher body mass index at all time points (baseline, P = 0.04; after weight loss, P = 0.05; after weight maintenance, P = 0.02). They also showed less overall weight loss ( P = 0.05), which derived mainly from a greater weight regain during the maintenance phase ( P = 0.02). Conclusion In this program, younger A1 + participants exhibited problems in maintaining weight loss during a weight-loss program. |
| Databáze: | OpenAIRE |
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