The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy
| Autor: | Coral Sanfeliu, Rubén Corpas, Aina Bellver-Sanchis, Joan Roig-Soriano, Miguel Chillón, Mercè Pallàs, Csaba Sőti, Milán Somogyvári, Vanessa Izquierdo, Christian Griñán-Ferré, Cristina Andres-Lacueva |
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| Přispěvatelé: | Institut Català de la Salut, [Griñán-Ferré C, Bellver-Sanchis A, Izquierdo V] Pharmacology Section, Department of Pharmacology, Toxicology, and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Barcelona, Spain. [Corpas R] Institut d’Investigacions Biomèdiques de Barcelona (IIBB), CSIC, IDIBAPS and CIBERESP, Barcelona, Spain. [Roig-Soriano J] Departament de Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain. Institut de Neurociènces (INc), Universitat Autònoma Barcelona, Bellaterra, Spain. [Chillón M] Departament de Bioquímica i Biologia Molecular, Universitat Autònoma Barcelona, Bellaterra, Spain. Institut de Neurociènces (INc), Universitat Autònoma Barcelona, Bellaterra, Spain. Grup de Recerca en Teràpia Gènica al Sistema Nerviós, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat Producció de Vectors (UPV), Universitat Autònoma Barcelona, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Hungarian Scientific Research Fund, Semmelweis University |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease [DISEASES] Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents [CHEMICALS AND DRUGS] Pharmacology Resveratrol medicine.disease_cause Other subheadings::Other subheadings::/drug therapy [Other subheadings] Biochemistry Antioxidants Epigenesis Genetic chemistry.chemical_compound 0302 clinical medicine Cognitive decline education.field_of_study Microbiota Neurodegeneration Malalties neurodegeneratives Epigenetic Neurodegenerative Diseases Neuroprotective Agents Neurology acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores [COMPUESTOS QUÍMICOS Y DROGAS] Epigenetics Epigenetic therapy trastornos mentales::trastornos neurocognitivos::trastornos cognitivos::disfunción cognitiva [PSIQUIATRÍA Y PSICOLOGÍA] Biotechnology Senescence Population Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] Gut microbiota Biology Neuroprotection Trastorns de la cognició Klotho 03 medical and health sciences Alzheimer Disease medicine Neurofarmacologia - Ús terapèutic Humans Cognitive Dysfunction education Molecular Biology Aged medicine.disease Epigenètica Oxidative Stress 030104 developmental biology chemistry enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer [ENFERMEDADES] Alzheimer Malaltia d' - Tractament Mental Disorders::Neurocognitive Disorders::Cognition Disorders::Cognitive Dysfunction [PSYCHIATRY AND PSYCHOLOGY] 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Scientia Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, the Central Nervous System (CNS) can benefit from nutritional strategies and dietary interventions that prevent signs of senescence, such as cognitive decline or neurodegenerative diseases such as Alzheimer¿s disease and Parkinson¿s Disease. The dietary polyphenol Resveratrol (RV) possesses antioxidant and cytoprotective effects, producing neuroprotection in several organisms. The oxidative stress (OS) occurs because of Reactive oxygen species (ROS) accumulation that has been proposed to explain the cause of the ageing. One of the most harmful effects of ROS in the cell is DNA damage. Nevertheless, there is also evidence demonstrating that OS can produce other molecular changes such as mitochondrial dysfunction, inflammation, apoptosis, and epigenetic modifications, among others. Interestingly, the dietary polyphenol RV is a potent antioxidant and possesses pleiotropic actions, exerting its activity through various molecular pathways. In addition, recent evidence has shown that RV mediates epigenetic changes involved in ageing and the function of the CNS that persists across generations. Furthermore, it has been demonstrated that RV interacts with gut microbiota, showing modifications in bacterial composition associated with beneficial effects. In this review, we give a comprehensive overview of the main mechanisms of action of RV in different experimental models, including clinical trials and discuss how the interconnection of these molecular events could explain the neuroprotective effects induced by RV. This study was supported by the Ministerio de Economía, Industria y Competitividad (Agencia Estatal de Investigación, AEI) and Fondo Europeo de Desarrollo Regional (MINECO-FEDER) (PID2019-106285RB and PCIN-2015-229, and Generalitat de Catalunya (2017 SGR 106) to M.P. The work was funded by grants from the Hungarian Science Foundation (OTKA K 116525), and from the Semmelweis University (STIA-KFI-2020/132257/AOMBT/2020) to C.S. |
| Databáze: | OpenAIRE |
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