Improvement effects of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich on postmenopausal symptoms of ovariectomized mice
Autor: | Na-Ra Han, Hosong Cho, Hyeong-Jin Kim, Hyung-Min Kim, Phil-Dong Moon, Sun-Young Nam, Hyun-Ja Jeong, Hee-Yun Kim, Boyoung Lee, Sungwei Hong |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Tectorigenin endocrine system Pueraria medicine.medical_specialty Citrus medicine.drug_class TEC Ovariectomy Estrogen receptor Flowers Tectoridin 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Internal medicine medicine Animals Pharmacology Mice Inbred BALB C 030219 obstetrics & reproductive medicine biology Plant Extracts General Medicine biology.organism_classification Postmenopause 030104 developmental biology Endocrinology Treatment Outcome chemistry Estrogen Hot Flashes Vagina Ovariectomized rat Drug Therapy Combination Female Luteinizing hormone hormones hormone substitutes and hormone antagonists Phytotherapy |
Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 103 |
ISSN: | 1950-6007 |
Popis: | Background Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes. Methods We examined the anti-hot flushes properties of PCE17, PE, CE, Tec, or Hes using a mouse model of ovariectomy-induced hot flushes. Results The ovariectomy-induced rise in the tail skin temperature was significantly prevented by PCE17, PE, CE, Tec, or Hes. PCE17, PE, CE, Tec, or Hes significantly enhanced 5-HT levels and attenuated RANKL levels in the hypothalamus of ovariectomized (OVX) mice. Treatment with PCE17, PE, CE, Tec, or Hes significantly enhanced the levels of estrogen receptor (ER)-β, 5-HT1A, 5-HT2A, and tryptophan hydroxylase mRNA expression in the hypothalamus of OVX mice. PCE17, PE, or CE decreased follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, but did not increase estrogen levels in the serum of OVX mice. Tec or Hes decreased FSH or LH levels and increased estrogen levels. Treatment with PCE17, PE, CE, or Tec ameliorated vaginal atrophy in OVX mice. Finally, PCE17, PE, CE, Tec, or Hes significantly increased norepinephrine and dopamine levels in the hypothalamus of OVX mice. Conclusion Thus, these results imply that PCE17 has protective effects against hot flushes. |
Databáze: | OpenAIRE |
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