Clinical phenotype and anti-desmoglein autoantibody profile in paraneoplastic pemphigus
| Autor: | Manabu Ohyama, Masayuki Amagai, Grant J. Anhalt, Hossein C. Nousari, Takeji Nishikawa, Takashi Hashimoto |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Paraneoplastic Syndromes Mucocutaneous zone Dermatology Desmoglein Immunophenotyping medicine Humans Aged Autoantibodies business.industry Desmoglein 1 Pemphigus vulgaris Autoantibody Antibody titer Middle Aged medicine.disease Cytoskeletal Proteins Pemphigus Paraneoplastic pemphigus Desmoplakins Immunology Female Desmogleins business Cell Adhesion Molecules |
| Zdroj: | Journal of the American Academy of Dermatology. 44:593-598 |
| ISSN: | 0190-9622 |
| Popis: | Background: Paraneoplastic pemphigus (PNP) has similar features to pemphigus vulgaris (PV), including circulating anti-desmoglein (Dsg) IgG as pathogenic autoantibodies. When PV is divided into mucosal dominant type and mucocutaneous type, mucosal dominant type has only anti-Dsg3 IgG, whereas the mucocutaneous type has both anti-Dsg3 and anti-Dsg1 IgG. Objective: The purpose of this study was to determine whether there is a difference in anti-Dsg autoantibody profile between mucosal dominant PNP and mucocutaneous PNP. Methods: Twenty-one patients with PNP were categorized as mucosal dominant and mucocutaneous types based on clinical information. Antibody titers against Dsg3 and Dsg1 were measured by enzyme-linked immunosorbent assay by means of recombinant Dsg1 and Dsg3. Results: There were 9 cases of mucosal dominant type and 12 cases of mucocutaneous type. Eight of 9 cases of mucosal dominant type were positive for anti-Dsg3 IgG, but 3 of them were also positive for anti-Dsg1 IgG. All 12 cases of mucocutaneous type were positive for anti-Dsg3 IgG, whereas only 6 of them were positive for anti-Dsg1 IgG. Conclusion: There was no clear association between the clinical phenotype and anti-Dsg antibody profile in PNP as seen in PV. This finding suggests that besides anti-Dsg IgG other pathologic mechanisms such as lichenoid reaction or interface dermatitis may be involved in the blister formation in PNP. (J Am Acad Dermatol 2001;44:593-8.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect