Genetic mouse models relevant to schizophrenia: Taking stock and looking forward
| Autor: | David Pritchett, Elizabeth M. Tunbridge, Paul Harrison, David M. Bannerman, Jill F. Betts, Wiebke Nissen, Katharina Stumpenhorst, Karri Lamsa, Trevor Sharp, Judith Schweimer, Philip W.J. Burnet, Tracy A. Lane |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Cognitive science Psychosis Rat model Construct validity medicine.disease Key issues Genetic architecture Developmental psychology Disease Models Animal Mice Cellular and Molecular Neuroscience Schizophrenia medicine Animals Humans Gene-Environment Interaction Genetic Predisposition to Disease Psychology |
| Zdroj: | Neuropharmacology. 62(3) |
| ISSN: | 1873-7064 0028-3908 |
| Popis: | Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue. This article is part of a Special Issue entitled 'Schizophrenia'. © 2011 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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