Acute hepatitis C in Korea: different modes of infection, high rate of spontaneous recovery, and low rate of seroconversion
| Autor: | Sook-Hyang Jeong, Ji Eon Won, Han Chu Lee, Sook-Kyoung Kang, Jong Yeop Kim, Seong Gyu Hwang, Sang Jong Park, Si Hyun Bae, Young Seok Kim |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Spontaneous recovery Remission Spontaneous Hepacivirus Antiviral Agents Young Adult Risk Factors Virology Epidemiology Republic of Korea Acupuncture medicine Humans Longitudinal Studies Seroconversion Needlestick Injuries Aged High rate biology business.industry Alanine Transaminase Hepatitis C Antibodies Middle Aged Hepatitis C Chronic infection Infectious Diseases Treatment Outcome Surgical Procedures Operative Acute Disease biology.protein RNA Viral Female Acute hepatitis C Antibody business |
| Zdroj: | Journal of medical virology. 83(7) |
| ISSN: | 1096-9071 |
| Popis: | The epidemiology and clinical outcomes of acute hepatitis C are different geographically. This study aimed to investigate the mode of infection, clinical characteristics, and outcomes of acute hepatitis C in Korea. Forty-seven patients with acute hepatitis C were enrolled consecutively in a study conducted in seven medical centers. The patients with the mean age of 45.8 years had mostly mild symptoms. A healthcare-related procedure was the most common exposure history (42.5%): acupuncture (17%), surgery (10.6%), needle-stick injury (8.5%), and other medical procedures (6.4%). There was no case of intravenous drug use. Twenty-one patients (44.7%) recovered spontaneously. Among the 16 patients who received antiviral therapy (34%), all of the 12 evaluable patients had a sustained virologic response, while 10 patients (21.3%) who did not receive antiviral therapy progressed to chronic infection. The overall seroconversion rate of anti-HCV antibody was 61.7%. The patients who recovered spontaneously had significantly lower rate of seroconversion compared with the patients who did not clear spontaneously the infection. In conclusion, acute hepatitis C in Korea was related to various healthcare procedures, including acupuncture, characterized by high rates of spontaneous recovery and low rates of seroconversion, which may be associated with different modes of infection and ethnic differences. The characteristics of acute hepatitis C in Asian countries warrants further study. |
| Databáze: | OpenAIRE |
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