Involvement of the reward network is associated with apathy in cerebral small vessel disease
| Autor: | Lisiecka-Ford, Danuta M., Tozer, Daniel J., Morris, Robin G., Lawrence, Andrew J., Barrick, Thomas R., Markus, Hugh S. |
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| Přispěvatelé: | Tozer, Daniel [0000-0002-0404-3214], Markus, Hugh [0000-0002-9794-5996], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
FSL
FMRIB Software Library Male small vessel disease neural network graph theory Apathy apathy Article Lacunar stroke Reward Humans Cognitive Dysfunction VTA ventral tagmental area AAL Automated Anatomical Labelling reward Aged Depressive Disorder Depression SVD small vessel disease GDS Geriatric Depression Scale Brain WMH white matter hyperintensities lacunar stroke SPGR spoiled gradient recalled echo Middle Aged Magnetic Resonance Imaging Neural network Small vessel disease Graph theory Stroke Diffusion Tensor Imaging SCANS St George's Cognition and Neuroimaging in Stroke Cerebral Small Vessel Diseases Female DTI diffusion tensor imaging Nerve Net MRI magnetic resonance imaging |
| Zdroj: | Lisiecka Ford, D M, Tozer, D, Morris, R G, Lawrence, A J, Barrick, T R & Markus, H S 2018, ' Involvement of the reward network is associated with apathy in cerebral small vessel disease ', Journal of Affective Disorders . https://doi.org/10.1016/j.jad.2018.02.006 Journal of Affective Disorders |
| ISSN: | 1573-2517 |
| DOI: | 10.1016/j.jad.2018.02.006 |
| Popis: | Introduction Apathy is a common yet under-recognised feature of cerebral small vessel disease (SVD), but its underlying neurobiological basis is not yet understood. We hypothesized that damage to the reward network is associated with an increase of apathy in patients with SVD. Methods In 114 participants with symptomatic SVD, defined as a magnetic resonance imaging confirmed lacunar stroke and confluent white matter hyperintensities, we used diffusion tensor imaging tractography to derive structural brain networks and graph theory to determine network efficiency. We determined which parts of the network correlated with apathy symptoms. We tested whether apathy was selectively associated with involvement of the reward network, compared with two “control networks” (visual and motor). Results Apathy symptoms negatively correlated with connectivity in network clusters encompassing numerous areas of the brain. Network efficiencies within the reward network correlated negatively with apathy scores; (r = − 0.344, p Highlights • Apathy is an important affective consequence of cerebral small vessel disease. • Our study investigates neuromechanism of apathy in small vessel disease. • We show that apathy is associated with structural disconnectivity in the reward network. |
| Databáze: | OpenAIRE |
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