Novel structures of platinum complexes bearing N‑bisphosphonates and study of their biological properties
| Autor: | Célia Fernandes, Filipa Mendes, Josefina Perles, Ana I. Matesanz, Amparo Alvarez-Valdés, Adoración G. Quiroga, João D. G. Correia |
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| Rok vydání: | 2019 |
| Předmět: |
Diphosphonates
Ligand Cationic polymerization chemistry.chemical_element Platinum Compounds DNA Crystallography X-Ray Biochemistry Combinatorial chemistry Inorganic Chemistry chemistry.chemical_compound Monomer chemistry Cell Line Tumor Animals Humans Cattle Chelation Isopropylamine Solubility Platinum |
| Zdroj: | Journal of Inorganic Biochemistry. 191:112-118 |
| ISSN: | 0162-0134 |
| Popis: | Novel bisphosphonate platinum complexes: [Pt(isopropylamine) 2 (BP)]NO 3 (BP = pamidronate and alendronate) have been synthesized and characterized. Their monomeric structure contains a bisphosphonate acting as chelate ligand through its oxygen atom donors, conferring the compound's cationic structure with a good solubility in water. The study of the compounds in solution showed high stability up to 24 h. The cytotoxicity in cancer cell lines has been assessed. We also present preliminary studies on the evaluation of the affinity towards biological targets such as DNA (both calf thymus DNA and supercoiled plasmid DNA) and hydroxyapatite where the complexes showed a low DNA interaction, but a clear affinity for hydroxyapatite comparing to their precursors. |
| Databáze: | OpenAIRE |
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