White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells
| Autor: | Cheng-Chih Hsiao, Aletta M R van den Bosch, Joost Smolders, Jörg Hamann, Nina L. Fransen, Inge Huitinga, Kim I.M. Brandwijk |
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| Přispěvatelé: | Experimental Immunology, AII - Inflammatory diseases, Graduate School, APH - Aging & Later Life, APH - Mental Health, ANS - Cellular & Molecular Mechanisms, Structural and Functional Plasticity of the nervous system (SILS, FNWI), Netherlands Institute for Neuroscience (NIN), Immunology, Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty tissue-resident memory T cells brain Immunology Cell Biology multiple sclerosis 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy CD20 human CD69 Multiple sclerosis medicine.disease Hyperintensity Granzyme B 030104 developmental biology medicine.anatomical_structure biology.protein CD8 030215 immunology |
| Zdroj: | European journal of immunology, 51(2), 483-486. Wiley-VCH Verlag European Journal of Immunology, 51, 483-486. Wiley-VCH Verlag European Journal of Immunology, 51(2), 483-486. Wiley-VCH |
| ISSN: | 0014-2980 |
| Popis: | Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS. |
| Databáze: | OpenAIRE |
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