Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis
| Autor: | Eduardus F. M. Posthuma, Anthonie P. C. van der Maas, Peter J. M. Valk, Frank A. Jacob, Hidde L. A. Posthuma, Radek C. Skoda |
|---|---|
| Přispěvatelé: | Hematology |
| Rok vydání: | 2010 |
| Předmět: |
Acute leukemia
medicine.medical_specialty Mutation Hematology Thrombocytosis business.industry Essential thrombocythemia fungi Immunology food and beverages Cancer hemic and immune systems Cell Biology medicine.disease medicine.disease_cause Biochemistry hemic and lymphatic diseases Internal medicine Medicine Platelet business Myelofibrosis circulatory and respiratory physiology |
| Zdroj: | Blood, 116(17), 3375-3376. American Society of Hematology |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2010-06-290718 |
| Popis: | To the editor: Essential thrombocythemia (ET) is frequently characterized by clonal hematopoiesis and an acquired JAK2-V617F mutation. Mutations in the thrombopoietin gene ( THPO ) and in the thrombopoietin receptor gene ( MPL ) can cause hereditary thrombocytosis (HT).[1][1] HT, like ET, can |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|