Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
| Autor: | Carrie A. Grueter, Brandon D. Turner, Daniel T. Kashima, Kevin M. Manz, Brad A. Grueter |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Serotonin Physiology Cognitive Neuroscience media_common.quotation_subject Glutamic Acid Anxiety Plasticity Nucleus accumbens Receptors N-Methyl-D-Aspartate Biochemistry Nucleus Accumbens Article 03 medical and health sciences Reward system 0302 clinical medicine Reward medicine Animals Humans Learning Receptors AMPA Receptors Cannabinoid media_common Motivation Neuronal Plasticity Depression Addiction Glutamate receptor Feeding Behavior Cell Biology General Medicine Behavior Addictive 030104 developmental biology Opioid Peptides Receptors Opioid Synaptic plasticity medicine.symptom Psychology Neuroglia Neuroscience 030217 neurology & neurosurgery Endocannabinoids |
| Zdroj: | ACS Chemical Neuroscience. 9:2114-2126 |
| ISSN: | 1948-7193 |
| Popis: | Synaptic plasticity contributes to behavioral adaptations. As a key node in the reward pathway, the nucleus accumbens (NAc) is important for determining motivation-to-action outcomes. Across animal models of motivation including addiction, depression, anxiety, and hedonic feeding, selective recruitment of neuromodulatory signals and plasticity mechanisms have been a focus of physiologists and behaviorists alike. Experience-dependent plasticity mechanisms within the NAc vary depending on the distinct afferents and cell-types over time. A greater understanding of molecular mechanisms determining how these changes in synaptic strength track with behavioral adaptations will provide insight into the process of learning and memory along with identifying maladaptations underlying pathological behavior. Here, we summarize recent findings detailing how changes in NAc synaptic strength and mechanisms of plasticity manifest in various models of motivational disorders. |
| Databáze: | OpenAIRE |
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