Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa
| Autor: | Ulrich Cuntz, Bärbel Otto, Peter Lehnert, R. L. Riepl, Manfred M. Fichter, Erich Frühauf, Paul Enck |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Anorexia Nervosa Hunger Eating Disorders lcsh:Medicine Gastroenterology and Hepatology Biology Anorexia nervosa Weight Gain Eating Endocrinology Internal medicine Surveys and Questionnaires medicine Humans lcsh:Science Eating habits Gastrin Cholecystokinin Nutrition Multidisciplinary Endocrine Physiology Bulimia nervosa Gastrointestinal Motility Disorders lcsh:R digestive oral and skin physiology Malnutrition Feeding Behavior Neuroendocrinology Middle Aged medicine.disease Hormones Eating disorders Medicine lcsh:Q Female medicine.symptom Weight gain hormones hormone substitutes and hormone antagonists Hormone Follow-Up Studies Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e54457 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Objective Despite a number of studies in the past decades, the role of Cholecystokinin (CCK) in anorexia nervosa (AN) has remained uncertain. In this study a highly specific assay for the biologically active part of CCK was used in patients with bulimic as well as with the restricting type of AN who were followed over the course of weight gain. Methods Ten patients with restricting and 13 with bulimic AN were investigated upon admission (T0), after a weight gain of at least 2 kg on two consecutive weighting dates (T1), and during the last week before discharge (T2) from inpatient treatment in a specialized clinic. Blood samples were drawn under fasting conditions and 20 and 60 minutes following a standard meal (250 kcal). Data were compared to those of eight controls matched for sex and age. Gastrointestinal complaints of patients were measured by a questionnaire at each of the follow-up time points. Results At admission, AN patients exhibited CCK-levels similar to controls both prior to and after a test meal. Pre and post-meal CCK levels increased significantly after an initial weight gain but decreased again with further weight improvement. CCK release was somewhat lower in bulimic than in restricting type AN but both subgroups showed a similar profile. There was no significant association of CCK release to either initial weight or BMI, or their changes, but CCK levels at admission predicted gastrointestinal symptom improvement during therapy. Conclusions Normal CCK profiles in AN at admission indicates hormonal responses adapted to low food intake while change of eating habits and weight gain results in initially increased CCK release (counteracting the attempts to alter eating behavior) that returns towards normal levels with continuous therapy. |
| Databáze: | OpenAIRE |
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