Effects of somatostatin on gastric secretion and gastrin release in man
| Autor: | L. von Berger, H.C. Dollinger, E. F. Pfeiffer, W. Schlegel, K. E. Schröder, Sotirios Raptis |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Hypophysectomy Gastric Juice Time Factors Chemistry medicine.medical_treatment digestive oral and skin physiology Gastroenterology Radioimmunoassay Growth hormone Growth hormone secretion Gastric secretion Endocrinology Somatostatin Internal medicine Gastrins medicine Humans Secretion Gastrin |
| Zdroj: | Digestion. 13(1-2) |
| ISSN: | 0012-2823 |
| Popis: | Somatostatin, a recently synthesized hypothalamic growth hormone release-inhibiting factor (GIF), was used in the cyclic and linear form. In all subjects studied, the cyclic GIF inhibited gastrin secretion during basal conditions as well as during a standard food stimulus, with immediate rebound after the infusion was stopped. Similar responses were observed in a hypophysectomized patient, indicating that this effect of GIF was independent of suppression of growth hormone secretion. Cyclic and linear GIF, when administered in normal subjects during an infusion of synthetic human gastrin I, almost totally suppressed gastric secretion. The results indicate that GIF is a potent inhibitor of gastric secretion and gastrin release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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