Prevalence and predictors of blood-brain barrier damage in the HAART era
| Autor: | Andrea Calcagno, Valeria Ghisetti, Daniele Imperiale, Stefania Raviolo, Stefano Bonora, Alessandra Romito, Sabrina Audagnotto, Filippo Lipani, G. Di Perri, Maria Chiara Alberione |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Neurology Central nervous system HIV Infections Vascular permeability Blood–brain barrier Capillary Permeability Central nervous system disease Cellular and Molecular Neuroscience Cerebrospinal fluid Risk Factors Antiretroviral Therapy Highly Active Virology Internal medicine Prevalence Humans Medicine Retrospective Studies business.industry Retrospective cohort study Middle Aged medicine.disease medicine.anatomical_structure Viral replication Blood-Brain Barrier Immunology Female Neurology (clinical) business |
| Zdroj: | Journal of NeuroVirology. 20:521-525 |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.1007/s13365-014-0266-2 |
| Popis: | Blood-brain barrier damage (BBBD) is prevalent in HIV-positive patients and may enhance cell trafficking to the central nervous system. A retrospective analysis in adult HIV-positive patients with no central nervous system disease was conducted in order to estimate the prevalence and risk factors of BBBD (according to cerebrospinal fluid to plasma albumin ratios). One hundred fifty-eight HIV-positive adult patients were included. BBBD impairment and intrathecal IgG synthesis were respectively observed in 45 (28.5 %) and 100 patients (63.3 %). Low CD4 nadir and high CSF HIV RNA were independently associated with both abnormalities. BBBD is common in HIV-positive patients, and its main determinants are advanced immune depression and compartmental viral replication. |
| Databáze: | OpenAIRE |
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