A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features
| Autor: | Laura J. Tafe, Konstantinos Linos, Alexander M. Strait, Kristen E. Muller |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty DNA Copy Number Variations Microarray Breast Neoplasms Male Pathology and Forensic Medicine Diagnosis Differential Neoplasms Muscle Tissue 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Breast Mammary-Type Myofibroblastoma Mitosis Aged Chromosomes Human Pair 13 biology Retinoblastoma protein medicine.disease Neoplasms Complex and Mixed Angiofibromas 030104 developmental biology 030220 oncology & carcinogenesis Spindle cell lipoma biology.protein Surgery Sarcoma Anatomy Myofibroblastoma |
| Zdroj: | International Journal of Surgical Pathology. 29:308-313 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/1066896920947465 |
| Popis: | Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breast of a 70-year old man that microscopically showed an abrupt transition from classic MFB morphology to an area with cytologic atypia and mitotic activity, akin to sarcomatous transformation described in cellular angiofibromas. A thorough workup of the molecular underpinnings of both components using chromosomal microarray and next-generation sequencing platforms supported a clonal relationship. Nearly identical copy number changes, including a single copy loss of 13q14, were found in both components; in addition, the sarcomatous component harbored biallelic TP53 alterations. It is important for pathologists to recognize that sarcomatous features can occur in mammary-type MFB to arrive at the correct diagnosis. |
| Databáze: | OpenAIRE |
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