Injectable Drug-Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction
| Autor: | Dong-Wei Gao, Huiliang Qiu, Maani M. Archang, Song Li, Xintong Zhong, Randall J. Lee, Richard E. Sievers, Mohammad Mahdi Hasani-Sadrabadi, Qizhi Fang, Jaekyung Koh, Dino Di Carlo, Jun Fang, Hiromi Miwa |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Angiogenesis Nanoparticle granular hydrogels Bioengineering Cardiovascular Regenerative Medicine Regenerative medicine Article Biomaterials microgels Engineering Tissue engineering Fibrosis Electrochemistry medicine Nanotechnology Materials Heart Disease - Coronary Heart Disease Microporous material Condensed Matter Physics medicine.disease Electronic Optical and Magnetic Materials myocardial infarction Heart Disease tissue engineering Drug delivery Self-healing hydrogels drug delivery Physical Sciences Chemical Sciences Biomedical engineering Biotechnology |
| Zdroj: | Adv Funct Mater Advanced functional materials, vol 30, iss 43 |
| ISSN: | 1616-301X |
| Popis: | Intramyocardial injection of hydrogels offers great potential for treating myocardial infarction (MI) in a minimally invasive manner. However, traditional bulk hydrogels generally lack microporous structures to support rapid tissue ingrowth and biochemical signals to prevent fibrotic remodeling toward heart failure. To address such challenges, a novel drug-releasing microporous annealed particle (drugMAP) system is developed by encapsulating hydrophobic drug-loaded nanoparticles into microgel building blocks via microfluidic manufacturing. By modulating nanoparticle hydrophilicity and pregel solution viscosity, drugMAP building blocks are generated with consistent and homogeneous encapsulation of nanoparticles. In addition, the complementary effects of forskolin (F) and Repsox (R) on the functional modulations of cardiomyocytes, fibroblasts, and endothelial cells in vitro are demonstrated. After that, both hydrophobic drugs (F and R) are loaded into drugMAP to generate FR/drugMAP for MI therapy in a rat model. The intramyocardial injection of MAP gel improves left ventricular functions, which are further enhanced by FR/drugMAP treatment with increased angiogenesis and reduced fibrosis and inflammatory response. This drugMAP platform represents a new generation of microgel particles for MI therapy and will have broad applications in regenerative medicine and disease therapy. |
| Databáze: | OpenAIRE |
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