Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation
| Autor: | Ian Wilcox, David S. Celermajer, M.R. Langenfeld, Michael R. Skilton, Jo-Dee L. Lattimore |
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| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Endothelium medicine.medical_treatment Vasodilation Microcirculation Nitric oxide chemistry.chemical_compound Forearm Internal medicine medicine.artery medicine Humans Continuous positive airway pressure Brachial artery Analysis of Variance Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry Middle Aged nervous system diseases respiratory tract diseases medicine.anatomical_structure Endocrinology Editorial chemistry Cardiovascular Diseases Cardiology Female Sodium nitroprusside Endothelium Vascular business Sleep Disordered Breathing Blood Flow Velocity medicine.drug |
| Zdroj: | Thorax. 61(6) |
| ISSN: | 0040-6376 |
| Popis: | Background: Obstructive sleep apnoea (OSA) is a common and potentially reversible cause of systemic hypertension. The mechanisms whereby OSA leads to hypertension and the effects of treatment on arterial function, however, are not well established. Microvascular arterial endothelial and smooth muscle function was assessed in subjects with OSA before and after treatment with continuous positive airways pressure (CPAP). Methods: Ten subjects of mean (SE) age 49 (8) years with at least moderately severe OSA had detailed forearm vascular reactivity studies before and after 3 months of CPAP treatment. The systemic circulation was assessed by measuring brachial artery pressure, flow and resistance responses to intra-arterial infusions of acetylcholine (ACh; an endothelium dependent vasodilator), sodium nitroprusside (SNP; an endothelium independent vasodilator), l-NMMA (a nitric oxide (NO) antagonist), and l-arginine (the substrate for NO). Results: Before CPAP, ACh and SNP infusions increased forearm blood flow in a dose dependent manner (p |
| Databáze: | OpenAIRE |
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