Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
| Autor: | Battista Di Gioia, Eleonora Ciaschi, Lorenzo Silvani, Maria Albanese, Barbara Chiaramonte, Francesco Maria Passali, Stefano Di Girolamo, Arianna Di Stadio, Nicola Biagio Mercuri, Matteo Conti |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Aura Triptans olivocochlear system Audiology transient-evoked otoacoustic emissions Article Settore MED/31 medicine otorhinolaryngologic diseases migraine CGRP distortion-product otoacoustic emissions Subclinical infection Vestibular system cochlear damage medicine.diagnostic_test business.industry General Medicine hearing impairment medicine.disease Allodynia Auditory brainstem response Migraine Medicine sense organs medicine.symptom Audiometry business medicine.drug |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 21 Journal of Clinical Medicine, Vol 10, Iss 5007, p 5007 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10215007 |
| Popis: | Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time. |
| Databáze: | OpenAIRE |
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