Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms
| Autor: | Katerina Mensikova, Jana Zapletalová, Štefan Sivák, Martin Nevrly, Jan Bardon, Miroslav Vastik, Petr Kanovsky, Pavel Otruba, Jan Valošek, Marketa Vecerkova, Petr Hluštík, David Krahulík, Monika Chudackova, Egon Kurča, Lenka Hvizdošová, Sandra Kurčová |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Deep brain stimulation
business.industry medicine.medical_treatment Deep Brain Stimulation Significant difference Stimulation Parkinson Disease Dorsolateral Anatomy General Biochemistry Genetics and Molecular Biology Subthalamic nucleus Treatment Outcome Deep brain stimulation electrode Subthalamic Nucleus Non motor Medicine Humans In patient business Electrodes |
| Zdroj: | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 166(1) |
| ISSN: | 1804-7521 |
| Popis: | Background: In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. Methods: The subthalamic nucleus was divided into two (dorsolateral/ventromedial) and three (dorsolateral, medial, ventromedial) parts. 37 deep brain stimulation electrodes were divided according to their active contact location. Correlation between change in non-motor symptoms before and one and four months after deep brain stimulation electrode implantation and the location of active contact was made. Results: In dividing the subthalamic nucleus into three parts, no electrode active contact was placed ventromedially, 28 active contacts were located in the medial part and 9 contacts were placed dorsolaterally. After one and four months, no significant difference was found between medial and dorsolateral positions. In the division of the subthalamic nucleus into two parts, 13 contacts were located in the ventromedial part and 24 contacts were placed in the dorsolateral part. After one month, significantly greater improvement in the Non-motor Symptoms Scale for Parkinson's disease (P=0.045) was found on dorsolateral left-sided stimulation, but no significant differences between the ventromedial and dorsolateral positions were found on the right side. Conclusion: This study demonstrated the relationship between improvement of non-motor symptoms and the side (hemisphere, left/right) of the deep brain stimulation electrode active contact, rather than its precise location within specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|