Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias
Autor: | Carlo de Asmundis, Sophie Van Malderen, Bernard Cosyns, Juan Sieira, Steven Droogmans, Gian-Battista Chierchia, Øyvind H. Lie, Pedro Brugada, Andreea Motoc, Esther Scheirlynck |
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Přispěvatelé: | Clinical sciences, Surgical clinical sciences, Internal Medicine, Faculty of Medicine and Pharmacy, Cardiology, Heartrhythmmanagement, Cardio-vascular diseases |
Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Heart Ventricles medicine.medical_treatment Speckle tracking echocardiography 030204 cardiovascular system & hematology Ventricular tachycardia Risk Assessment sudden cardiac death RISK STRATIFICATION Sudden cardiac death Electrocardiography 03 medical and health sciences 0302 clinical medicine SPECKLE TRACKING ECHOCARDIOGRAPHY Internal medicine medicine Humans cardiovascular diseases 030212 general & internal medicine Brugada Syndrome Brugada syndrome Ejection fraction business.industry fungi Middle Aged Prognosis Implantable cardioverter-defibrillator medicine.disease Myocardial Contraction Biomechanical Phenomena Death Sudden Cardiac medicine.anatomical_structure Echocardiography Ventricle Ventricular fibrillation Ventricular arrhythmia Tachycardia Ventricular Cardiology Female Cardiology and Cardiovascular Medicine business |
Zdroj: | International Journal of Cardiology. 299:147-152 |
ISSN: | 0167-5273 |
Popis: | Background Brugada syndrome (BrS) is characterized by a high risk of sudden cardiac death. The clinical value of deformation imaging in patients with BrS is unknown. We aimed to assess whether echocardiographic speckle tracking parameters differ between: 1) BrS patients and healthy controls, 2) BrS patients with and without life-threatening ventricular arrhythmias. Methods Left ventricle (LV) and right ventricle (RV) longitudinal strain and mechanical dispersion (MD) were derived from echocardiography at inclusion. Clinical and ECG data were retrospectively assessed. A life-threatening ventricular arrhythmia was defined as an aborted cardiac arrest or sustained ventricular tachyarrhythmia. Results We included 175 BrS patients and 82 controls. LV and RV longitudinal strain were lower (−18.1 ± 2.6% vs. −18.8 ± 2.0%, p = 0.01 and − 24.4 ± 5.4% vs. 25.6 ± 3.7%, p = 0.04), while MD was higher [38 ± 11 ms vs. 33 ± 8 ms, p = 0.001 and 15 (8–25) ms vs. 11 (6–19) ms, p = 0.03] in BrS patients compared to controls. BrS patients who experienced a life-threatening ventricular arrhythmia (n = 19) had higher LV MD compared to those without events (43 ± 11 ms vs. 37 ± 11 ms, p = 0.02). An LV MD ≥40 ms was optimally associated with life-threatening ventricular arrhythmias [odds ratio 4.62 (95%CI 1.58–13.50), p = 0.005]. Conclusions BrS patients had lower longitudinal strain and more heterogeneous contractions than healthy controls. Furthermore, BrS patients with a history of life-threatening ventricular arrhythmia had more heterogeneous LV contractions than those without. Therefore, LV MD may be a risk marker in BrS and its evaluation in prospective studies is needed. |
Databáze: | OpenAIRE |
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