Epigenetic remodeling of the fungal secondary metabolome
| Autor: | Robert H. Cichewicz, Russell B. Williams, Jon C. Henrikson, Andrlynn E. Lee, Ashley R. Hoover |
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| Rok vydání: | 2008 |
| Předmět: |
Natural product
Magnetic Resonance Spectroscopy Organic Chemistry Fungi RNA Biology Biochemistry DNA methyltransferase Mass Spectrometry Epigenesis Genetic chemistry.chemical_compound chemistry RNA Ribosomal Chemical diversity Metabolome Spectrophotometry Ultraviolet Histone deacetylase Epigenetics Chromatography Thin Layer Physical and Theoretical Chemistry Chromatography High Pressure Liquid Epigenesis |
| Zdroj: | Organicbiomolecular chemistry. 6(11) |
| ISSN: | 1477-0520 |
| Popis: | Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules. |
| Databáze: | OpenAIRE |
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