Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss

Autor:	Ning Yu, Liwei Chen, Shiming Yang, Yan Lu, Wei Sun, Daishi Chen, Ming-Kun Han, Xuejun Sun, Suoqiang Zhai
Rok vydání:	2017
Předmět:	Male 0301 basic medicine medicine.medical_specialty Hearing loss medicine.medical_treatment Guinea Pigs Sodium Chloride HMGB1 03 medical and health sciences 0302 clinical medicine Noise exposure Internal medicine Evoked Potentials Auditory Brain Stem medicine Animals Saline Cochlea biology Chemistry Deoxyguanosine General Medicine medicine.disease Disease Models Animal 030104 developmental biology Endocrinology Hearing Loss Noise-Induced Otorhinolaryngology 8-Hydroxy-2'-Deoxyguanosine Immunology biology.protein Cytokines Female Tumor necrosis factor alpha Inflammation Mediators medicine.symptom 030217 neurology & neurosurgery Intracellular Noise-induced hearing loss Hydrogen
Zdroj:	Acta Oto-Laryngologica. 137:1063-1068
ISSN:	1651-2251 0001-6489
Popis:	This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL.Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear physiology changes. The changes of 8-hydroxy-desoxyguanosine (8-HOdG), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group box-1 protein (HMGB1) in the cochlea were also examined.The results showed that pre-treatment with hydrogen-saturated saline could significantly attenuate noise-induced hearing loss. The concentration of 8-HOdG was also significantly decreased in the hydrogen-saturated saline group compared with the normal saline group. After noise exposure, the concentrations of IL-1, IL-6, TNF-α, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group. The concentrations of HMGB-1 and IL-10 in the hydrogen-saturated saline group were significantly higher than in those in the normal saline group immediately and at 7 d after noise exposure.This study revealed for the first time the protective effects of hydrogen-saturated saline on noise-induced hearing loss (NIHL) are related to both the anti-oxidative activity and anti-inflammatory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be1163fa3a6b3c32482eb48d0f9f5f3 https://doi.org/10.1080/00016489.2017.1328743 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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