Fast and sharp decrease in calprotectin predicts remission by infliximab in anti-TNF naive patients with ulcerative colitis
| Autor: | M, De Vos, O, Dewit, G, D'Haens, F, Baert, F, Fontaine, S, Vermeire, D, Franchimont, T, Moreels, D, Staessen, L, Terriere, B, Vander Cruyssen, E, Louis, Vermeire |
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| Přispěvatelé: | AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Time Factors RELAPSE Inflammatory bowel disease Gastroenterology Feces FECAL CALPROTECTIN fluids and secretions Medicine and Health Sciences EARLY RESPONSE Prospective Studies Young adult Prospective cohort study Sigmoidoscopy Anti-Inflammatory Agents Non-Steroidal Remission Induction Antibodies Monoclonal General Medicine Induction Chemotherapy Middle Aged Ulcerative colitis CROHNS-DISEASE Treatment Outcome Disease Progression Female medicine.drug Adult medicine.medical_specialty Adolescent Young Adult Internal medicine medicine Ulcerative Colitis Humans LACTOFERRIN Colitis Aged Calprotectin Dose-Response Relationship Drug business.industry Tumor Necrosis Factor-alpha medicine.disease Faecal calprotectin Infliximab Surgery MARKER Colitis Ulcerative Human medicine business Leukocyte L1 Antigen Complex Biomarkers INFLAMMATORY-BOWEL-DISEASE Follow-Up Studies |
| Zdroj: | Journal of Crohn s & colitis, 6(5), 557-562. Elsevier Journal of Crohn's and colitis JOURNAL OF CROHNS & COLITIS |
| ISSN: | 1873-9946 |
| DOI: | 10.1016/j.crohns.2011.11.002 |
| Popis: | Aim: To evaluate the effect of infliximab induction therapy on calprotectin levels in patients with ulcerative colitis (UC). Patients and Methods: In this prospective study 53 patients with active UC from 17 centers were treated with infliximab therapy (5 mg/kg) at baseline, week 2, and week 6. Faecal calprotectin was measured every week. Sigmoidoscopies were performed at baseline, week 6 and week 10. Results: Median calprotectin levels decreased from 1260 (IQR 278.5- 3418) at baseline to 72.5 (IQR 18.5 - 463) at week 10 (p |
| Databáze: | OpenAIRE |
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