Treatment of Periodontal Endosseous Defects With Platelet-Rich Plasma Alone or in Combination With Demineralized Freeze-Dried Bone Allograft: A Comparative Clinical Trial

Autor: Markou, N., Pepelassi, E., Vavouraki, H., Stamatakis, H. C., Nikolopoulos, Georgios K., Vrotsos, I., Tsiklakis, K.
Přispěvatelé: Nikolopoulos, Georgios K.[0000-0002-3307-0246]
Rok vydání: 2009
Předmět:
Male
Gingival and periodontal pocket
medicine.medical_treatment
Alveolar Bone Loss
Dentistry
Gingival recession
Periodontal pocket
Alveoloplasty
Bone transplantation
Controlled clinical trial
Image Processing
Computer-Assisted
Gingival Recession
Treatment outcome
Middle aged
Bone Transplantation
Platelet-Rich Plasma
Alveolar bone loss
Decalcification Technique
Thrombocyte rich plasma
Double blind procedure
Middle Aged
Clinical trial
Treatment Outcome
Randomized controlled trial
Periodontics
Female
Tissue Preservation
Periodontal disease
medicine.symptom
Human
Adult
Homologous
Histology
Double-blind method
Subtraction technique
Tissue preservation
Follow-up studies
Article
Gingiva disease
Oral surgery
Double-Blind Method
Image processing
Platelet-rich plasma
Periodontal Attachment Loss
medicine
Periodontal Pocket
Transplantation
Homologous
Humans
Image subtraction
Regeneration
Computer-assisted
Decalcification technique
Aged
Cryopreservation
Periodontitis
Transplantation
business.industry
Methodology
Allotransplantation
Follow up
Periodontal attachment loss
medicine.disease
Chronic periodontitis
Freeze Drying
Clinical attachment loss
Subtraction Technique
Chronic Periodontitis
Freeze drying
Comparative study
business
Controlled study
Follow-Up Studies
Zdroj: Journal of periodontology
ISSN: 1943-3670
0022-3492
DOI: 10.1902/jop.2009.090216
Popis: Background: Platelet-rich plasma (PRP) alone or combined with other regenerative materials was previously studied in human periodontal endosseous defects. There are no sufficient data evaluating to what extent the addition of demineralized freeze-dried bone allograft (DFDBA) to PRP may enhance the effectiveness of PRP. The aim of this randomized, double-masked, controlled clinical trial was to compare the effectiveness of autologous PRP alone or a PRP + combination in periodontal endosseous defects. Methods: Twenty-four proximal endosseous defects in 24 patients with severe chronic periodontitis were randomly treated with PRP alone or in combination with DFDBA. The final evaluation at 6 months was based on clinical and radiographic parameters. Subtraction radiography was used. The primary outcome variable was clinical attachment level (CAL). Results: The two treatment groups were initially comparable (mean CAL: 8.67 ± 2.19 mm for PRP + DFDBA and 8.25 ± 1.96 mm for PRP). Both treatments achieved statistically significant and similar CAL gain (3.08 ± 1.17 mm for PRP + DFDBA and 3.08 ± 0.95mmfor PRP), probing depth, defect depth, and area surface reduction. The percentage of defect fill did not significantly differ between the two treatments. There was a non-significant trend to greater defect fill (45.42% versus 41.29%), defect depth (54.05% versus 49.52%), and area surface (58.43% versus 52.16%) reduction with the graft. In both groups, 66.66% of the defects gained ≥3 mm of CAL. Conclusion: Within its limits, this study demonstrated that both PRP and PRP combined with DFDBA resulted in significant clinical and radiographic improvement inhuman periodontal endosseous defects at 6 months, and the addition of DFDBA to PRP did not significantly enhance the treatment outcome. J Periodontol 2009;80:1911-1919. 80 12 1911 1919
Databáze: OpenAIRE
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