Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes: secondary analyses of the DALI lifestyle randomized controlled trial

Autor: Van Poppel, M. N. M., Corcoy, R., Hill, D., Simmons, D., Mendizabal, L., Zulueta, M., Simon, L., Desoye, G., Adelantado Perez, J. M., Kautzky-Willer, A., Harreiter, J., Damm, P., Mathiesen, E., Jensen, D. M., Andersen, L. L. T., Dunne, F., Lapolla, A., Dalfra, M. G., Bertolotto, A., Van Poppel, M., Jelsma, J. G. M., Snoek, F. J., Galjaard, S., Wender-Ozegowska, E., Zawiejska, A., Devlieger, R.
Přispěvatelé: Public and occupational health, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, Medical Psychology
Rok vydání: 2021
Předmět:
Zdroj: Van Poppel, M N M, Corcoy, R, Hill, D, Simmons, D, Mendizabal, L, Zulueta, M, Simon, L, Desoye, G, DALI Core Investigator group, Jensen, D M & Andersen, L L T 2022, ' Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes : secondary analyses of the DALI lifestyle randomized controlled trial ', American Journal of Clinical Nutrition, vol. 115, no. 2, pp. 388-396 . https://doi.org/10.1093/ajcn/nqab347
American Journal of Clinical Nutrition, 115(2), 388-396. American Society for Nutrition
DALI Core Investigator Group 2022, ' Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes : secondary analyses of the DALI lifestyle randomized controlled trial ', American Journal of Clinical Nutrition, vol. 115, no. 2, pp. 388-396 . https://doi.org/10.1093/ajcn/nqab347
American journal of clinical nutrition, 115(2), 388-396. American Society for Nutrition
ISSN: 1938-3207
0002-9165
DOI: 10.1093/ajcn/nqab347
Popis: Background: Interactions between polymorphisms of the melatonin receptor 1B (MTNR1B) gene and lifestyle intervention for gestational diabetes have been described. Whether these are specific for physical activity or the healthy eating intervention is unknown. Objectives: The aim was to assess the interaction between MTNR1B rs10830962 and rs10830963 polymorphisms and lifestyle interventions during pregnancy. Methods: Women with a BMI (in kg/m2) of ≥29 (n = 436) received counseling on healthy eating (HE), physical activity (PA), or both. The control group received usual care. This secondary analysis had a factorial design with comparison of HE compared with no HE and PA compared with no PA. Maternal outcomes at 24-28 wk were gestational weight gain (GWG), maternal fasting glucose, insulin, insulin resistance (HOMA-IR), disposition index, and development of GDM. Neonatal outcomes were cord blood leptin and C-peptide and estimated neonatal fat percentage. The interaction between receiving either the HE or PA intervention and genotypes of both rs10830962 and rs10830963 was assessed using multilevel regression analysis. Results: GDM risk was increased in women homozygous for the G allele of rs10830962 (OR: 2.60; 95% CI: 1.34, 5.06) or rs10830963 (OR: 2.83; 95% CI: 1.24, 6.47). Significant interactions between rs10830962 and interventions were found: in women homozygous for the G allele but not in the other genotypes, the PA intervention reduced maternal fasting insulin (β: -0.16; 95% CI: -0.33, 0.02; P = 0.08) and HOMA-IR (β: -0.17; 95% CI: -0.35, 0.01; P = 0.06), and reduced cord blood leptin (β: -0.84; 95% CI: -1.42, -0.25; P = 0.01) and C-peptide (β: -0.62; 95% CI: -1.07, -0.17; P = 0.01). In heterozygous women, the HE intervention had no effect, whereas in women homozygous for the C allele, HE intervention reduced GWG (β: -1.6 kg; 95% CI: -2.4, -0.8 kg). No interactions were found. Conclusions: In women homozygous for the risk allele of MTNR1B rs10830962, GDM risk was increased and PA intervention might be more beneficial than HE intervention for reducing maternal insulin resistance, cord blood C-peptide, and cord blood leptin.
Databáze: OpenAIRE
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