Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

Autor: Fabio Magrini, Federico Lombardi, Daniela Mari, Emanuela Pettenuzzo, Gabriella Malfatto, Paola Nicolini, Dario Consonni, Paolo Dionigi Rossi, Carlo Abbate, Michele M. Ciulla
Rok vydání: 2014
Předmět:
Male
Aging
Supine position
Physiology
lcsh:Medicine
Neuropsychological Tests
Nervous System
Electrocardiography
Cognition
Geriatric Nursing
Heart Rate
Medicine and Health Sciences
Heart rate variability
lcsh:Science
Aged
80 and over
Geriatrics
education.field_of_study
Multidisciplinary
Cognitive Neurology
Electrophysiology
Neurology
Research Design
Cardiology
Female
Anatomy
Geriatric Cardiology
Research Article
medicine.medical_specialty
Clinical Research Design
Cognitive Neuroscience
Population
Autonomic Nervous System
Research and Analysis Methods
Internal medicine
Mental Health and Psychiatry
Heart rate
medicine
Humans
Dementia
Cognitive Dysfunction
education
Aged
Demography
Balance (ability)
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Cross-Sectional Studies
Blood pressure
Case-Control Studies
Physical therapy
Cognitive Science
lcsh:Q
business
Organism Development
Developmental Biology
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e96656 (2014)
ISSN: 1932-6203
Popis: Background Mild cognitive impairment (MCI) is set to become a major health problem with the exponential ageing of the world's population. The association between MCI and autonomic dysfunction, supported by indirect evidence and rich with clinical implications in terms of progression to dementia and increased risk of mortality and falls, has never been specifically demonstrated. Aim To conduct a comprehensive assessment of autonomic function in subjects with MCI by means of power spectral analysis (PSA) of heart rate variability (HRV) at rest and during provocative manoeuvres. Methods This cross-sectional study involved 80 older outpatients (aged ≥65) consecutively referred to a geriatric unit and diagnosed with MCI or normal cognition (controls) based on neuropsychological testing. PSA was performed on 5-minute electrocardiographic recordings under three conditions—supine rest with free breathing (baseline), supine rest with paced breathing at 12 breaths/minute (parasympathetic stimulation), and active standing (orthosympathetic stimulation)—with particular focus on the changes from baseline to stimulation of indices of sympathovagal balance: normalized low frequency (LFn) and high frequency (HFn) powers and the LF/HF ratio. Blood pressure (BP) was measured at baseline and during standing. Given its exploratory nature in a clinical population the study included subjects on medications with a potential to affect HRV. Results There were no significant differences in HRV indices between the two groups at baseline. MCI subjects exhibited smaller physiological changes in all three HRV indices during active standing, consistently with a dysfunction of the orthosympathetic system. Systolic BP after 10 minutes of standing was lower in MCI subjects, suggesting dysautonomia-related orthostatic BP dysregulation. Conclusions Our study is novel in providing evidence of autonomic dysfunction in MCI. This is associated with orthostatic BP dysregulation and the ongoing follow-up of the study population will determine its prognostic relevance as a predictor of adverse health outcomes.
Databáze: OpenAIRE
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