Post-weaning protein malnutrition increases blood pressure and induces endothelial dysfunctions in rats

Autor: Dalton Valentim Vassallo, Aucelia C. S. de Belchior, Edna Aparecida Silveira, Thaís de Oliveira Faria, Carlos Peres Da Costa, Alessandra Simão Padilha, Eduardo Frizzera Meira, Fabiana Dayse Magalhães Siman, Jhuli Keli Angeli
Rok vydání: 2011
Předmět:
Male
Low protein
Anatomy and Physiology
Protein–energy malnutrition
lcsh:Medicine
Blood Pressure
Cardiovascular
Cardiovascular System
Pediatrics
chemistry.chemical_compound
Phenylephrine
Heart Rate
Molecular Cell Biology
Vasoconstrictor Agents
Enzyme Inhibitors
lcsh:Science
Cellular Stress Responses
Multidisciplinary
Animal Models
Signaling Cascades
medicine.anatomical_structure
Nephrology
Hypertension
Medicine
medicine.drug
Artery
Research Article
Signal Transduction
medicine.medical_specialty
Endothelium
Nitric Oxide Synthase Type III
Weaning
Protein-Energy Malnutrition
Stress Signaling Cascade
Nitric oxide
Model Organisms
Vascular Biology
Internal medicine
medicine
Animals
Rats
Wistar
Biology
Nutrition
business.industry
lcsh:R
Body Weight
Malnutrition
Acetophenones
medicine.disease
Rats
Endocrinology
Blood pressure
chemistry
Apocynin
Rat
lcsh:Q
Endothelium
Vascular
business
Zdroj: PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e34876 (2012)
ISSN: 1932-6203
Popis: Malnutrition during critical periods in early life may increase the subsequent risk of hypertension and metabolic diseases in adulthood, but the underlying mechanisms are still unclear. We aimed to evaluate the effects of post-weaning protein malnutrition on blood pressure and vascular reactivity in aortic rings (conductance artery) and isolated-perfused tail arteries (resistance artery) from control (fed with Labina®) and post-weaning protein malnutrition rats (offspring that received a diet with low protein content for three months). Systolic and diastolic blood pressure and heart rate increased in the post-weaning protein malnutrition rats. In the aortic rings, reactivity to phenylephrine (10(-10)-3.10(-4) M) was similar in both groups. Endothelium removal or L-NAME (10(-4) M) incubation increased the response to phenylephrine, but the L-NAME effect was greater in the aortic rings from the post-weaning protein malnutrition rats. The protein expression of the endothelial nitric oxide isoform increased in the aortic rings from the post-weaning protein malnutrition rats. Incubation with apocynin (0.3 mM) reduced the response to phenylephrine in both groups, but this effect was higher in the post-weaning protein malnutrition rats, suggesting an increase of superoxide anion release. In the tail artery of the post-weaning protein malnutrition rats, the vascular reactivity to phenylephrine (0.001-300 µg) and the relaxation to acetylcholine (10(-10)-10(-3) M) were increased. Post-weaning protein malnutrition increases blood pressure and induces vascular dysfunction. Although the vascular reactivity in the aortic rings did not change, an increase in superoxide anion and nitric oxide was observed in the post-weaning protein malnutrition rats. However, in the resistance arteries, the increased vascular reactivity may be a potential mechanism underlying the increased blood pressure observed in this model.
Databáze: OpenAIRE
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