The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia
Autor: | Eunice S. Wang, Deedra Nicolet, Andrew J. Carroll, A-K Eisfeld, Clara D. Bloomfield, Christopher J. Walker, Shelley Orwick, Jonathan E. Kolitz, Richard Stone, James S. Blachly, A de la Chapelle, John C. Byrd, Karl Kroll, Jessica Kohlschmidt, Krzysztof Mrózek, Bayard L. Powell |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Myeloid medicine.medical_treatment DNA Mutational Analysis Gene mutation Biology Targeted therapy 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases medicine Humans Aged Chromosome Aberrations Acute leukemia Age Factors Myeloid leukemia Cancer Hematology DNA Neoplasm Middle Aged medicine.disease 3. Good health Leukemia Leukemia Myeloid Acute 030104 developmental biology medicine.anatomical_structure Gene Ontology 030220 oncology & carcinogenesis Karyotyping Immunology Mutation Original Article Female Genes Neoplasm |
Zdroj: | Leukemia |
ISSN: | 1476-5551 0887-6924 |
Popis: | Recurrent chromosomal abnormalities and gene mutations detected at the time of diagnosis of acute myeloid leukemia (AML) are associated with particular disease features, treatment response and survival of AML patients, and are used to denote specific disease entities in the World Health Organization classification of myeloid neoplasms and acute leukemia. However, large studies that integrate cytogenetic and comprehensive mutational information are scarce. We created a comprehensive oncoprint of mutations associated with recurrent cytogenetic findings by combining the information on mutational patterns of 80 cancer- and leukemia-associated genes with cytogenetic findings in 1603 adult patients with de novo AML. We show unique differences in the mutational profiles among major cytogenetic subsets, identify novel associations between recurrent cytogenetic abnormalities and both specific gene mutations and gene functional groups, and reveal differences in cytogenetic and mutational features between patients younger than 60 years and those aged 60 years or older. The identified associations between cytogenetic and molecular genetic data may help guide mutation testing in AML, and result in more focused application of targeted therapy in patients with de novo AML. |
Databáze: | OpenAIRE |
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