Facilitatory effect of paired-pulse stimulation by transcranial magnetic stimulation with biphasic wave-form
| Autor: | Gustaf Järnefelt, Jarmo Laine, Petri Savolainen, Jari Karhu, Petro Julkunen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Biophysics Stimulation Electromyography Stimulus (physiology) gamma-Aminobutyric acid 03 medical and health sciences 0302 clinical medicine medicine Humans Muscle Skeletal medicine.diagnostic_test Chemistry Interstimulus interval Transcranial Magnetic Stimulation Surgery Transcranial magnetic stimulation 030104 developmental biology medicine.anatomical_structure Intracortical facilitation Female 030217 neurology & neurosurgery Motor cortex medicine.drug Biomedical engineering |
| Zdroj: | Medical Engineering & Physics. 38:813-817 |
| ISSN: | 1350-4533 |
| DOI: | 10.1016/j.medengphy.2016.04.025 |
| Popis: | Transcranial magnetic stimulation (TMS) is used to probe corticospinal excitability by stimulating the motor cortex. Our aim was to enhance the effects of biphasic TMS by coupling a suprathreshold test pulse and a following subthreshold priming pulse to induce short-interval intracortical facilitation (SICF), which is conventionally produced with monophasic TMS. Biphasic TMS could potentially induce the SICF effect with better energy-efficiency and with lower stimulus intensities. This would make the biphasic paired-pulses better applicable in patients with reduced cortical excitability. A prototype stimulator was built to produce biphasic paired-pulses. Resting motor thresholds (rMTs) from the right and left hand abductor pollicis brevis muscles, and the right tibialis anterior muscle of eight healthy volunteers were determined using single-pulse paradigm with neuronavigated TMS. The rMTs and MEPs were measured using single-pulses and three paired-pulse setups (interstimulus interval, ISI of 3, 7 or 15ms). The rMTs were lower and MEPs were higher with biphasic paired-pulses compared to single-pulses. The SICF effect was greatest at 3ms ISI. This suggests that the application of biphasic paired-pulses to enhance stimulation effects is possible. |
| Databáze: | OpenAIRE |
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