Drug Absorption from the Small Intestine of the Triparanol-Treated Rat in Situ
| Autor: | V. M. K. Venho |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Quinidine
Drug Absorption (pharmacology) medicine.medical_specialty media_common.quotation_subject Mecamylamine Pharmacology Toxicology 030226 pharmacology & pharmacy Intestinal absorption 03 medical and health sciences 0302 clinical medicine Triparanol Internal medicine Intestine Small Isoniazid medicine Animals 030304 developmental biology media_common Whole blood 0303 health sciences Chemistry Small intestine Rats 3. Good health Endocrinology medicine.anatomical_structure Intestinal Absorption Phenobarbital Injections Intravenous Female Sulfisoxazole medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 39:321-330 |
| ISSN: | 0001-6683 |
| Popis: | The effect of treatment with triparanol (25 mg/kg by gavage every 24 hours for three weeks) on the absorption of phenobarbitone, sulphafurazole, isoniazid, mecamylamine and quinidine from the rat small intestine was studied in situ by measuring their disappearance from the intestinal lumen. The appearance of sulphafurazole and mecamylamine in the intestinal lumen was also studied after their intravenous administration, and the partitioning of mecamylamine between the buffer solution and the intestinal tissue was measured in vitro. Treatment with triparanol retarded the absorption of sulphafurazole, whereas the absorption of mecamylamine was accelerated. The amount of sulphafurazole and mecamylamine in the intestinal lumen after their intravenous administration was relatively slight. The in vitro partitioning of mecamylamine into the intestinal tissue was higher in triparanol–treated than in control intestines. Triparanol did not change the absorption of phenobarbitone, isoniazid or quinidine. Phenobarbitone in the whole blood at the end of the experiment was increased after triparanol, but the levels of other drugs were unchanged. Triparanol did not modify drug concentrations in the intestinal wall at the end of the experiment. The relatively slight changes in drug absorption induced by triparanol are probably due to changes in the morphology and composition of the intestinal wall. |
| Databáze: | OpenAIRE |
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