Boric Acid Induced Transient Cross-Links in Lactose-Modified Chitosan (Chitlac)
| Autor: | Michela Cok, Ivan Donati, Sergio Paoletti, Pasquale Sacco, Eleonora Marsich, Massimiliano Borgogna, Franco Furlani, Andrea Travan |
|---|---|
| Přispěvatelé: | Sacco, Pasquale, Furlani, Franco, Cok, Michela, Travan, Andrea, Borgogna, Masimiliano, Marsich, Eleonora, Paoletti, Sergio, Donati, Ivan |
| Rok vydání: | 2017 |
| Předmět: |
Circular dichroism
Magnetic Resonance Spectroscopy Polymers and Plastics Macromolecular Substances transient cross-links Biocompatible Materials Lactose Bioengineering 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Biomaterials Chitosan Boric acid chemistry.chemical_compound Boric Acids shear-thckening Dynamic light scattering Polysaccharides Materials Chemistry non-linear behavior Organic chemistry Lactose-modified chitosan chemistry.chemical_classification Viscosity Viscometer Nuclear magnetic resonance spectroscopy 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry rheology 0210 nano-technology boric acid Macromolecule Nuclear chemistry |
| Zdroj: | Biomacromolecules. 18:4206-4213 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | The present paper explores the effect of boric acid on Chitlac, a lactose-modified chitosan which had previously shown interesting biological and physical-chemical features. The herewith-reported experimental evidences demonstrated that boric acid binds to Chitlac, producing conformational and association effects on the chitosan derivative. The thermodynamics of boric acid binding to Chitlac was explored by means of 11B NMR, circular dichroism (CD), and UV–vis spectroscopy, while macromolecular effects were investigated by means of viscometry and dynamic light scattering (DLS). The experimental results revealed a chain–chain association when limited amounts of boric acid were added to Chitlac. However, upon exceeding a critical boric acid limit dependent on the polysaccharide concentration, the soluble aggregates disentangle. The rheological behavior of Chitlac upon treatment with boric acid was explored showing a dilatant behavior in conditions of steady flow. An uncommonly high dependence in the scaling law between the zero-shear viscosity and the concentration of Chitlac was found, i.e., η0 ∝ CCTL5.8, pointing to interesting potential implications of the present system in biomaterials development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|