Thalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor
| Autor: | Stefanie T Jost, Veerle Visser-Vandewalle, Jan N. Petry-Schmelzer, Josef Kessler, Tabea Thies, Jochen Wirths, Haidar S. Dafsari, Michael T. Barbe, Till A. Dembek, Gereon R. Fink, Hannah Jergas, Julia K. Steffen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Neurological signs
Dorsum Deep brain stimulation medicine.medical_treatment Stimulation Article lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine ddc:570 thalamic DBS Medicine tremor classification Prospective cohort study essential tremor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology 0303 health sciences Essential tremor business.industry General Neuroscience Active electrode medicine.disease ET plus Action tremor nervous system diseases deep brain stimulation surgical procedures operative Anesthesia business 030217 neurology & neurosurgery |
| Zdroj: | Brain Sciences, Vol 10, Iss 970, p 970 (2020) Brain Sciences Brain Sciences 10(12), 970-(2020). doi:10.3390/brainsci10120970 Volume 10 Issue 12 |
| ISSN: | 2076-3425 |
| DOI: | 10.3390/brainsci10120970 |
| Popis: | The new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects in ET-p. 44 patients with medication-refractory ET and thalamic/subthalamic DBS implanted at our center were postoperatively classified into ET and ET-p according to preoperative documentation. Tremor suppression with DBS (stimulation ON vs. preoperative baseline and vs. stimulation OFF), measured via the Fahn&ndash Tolosa&ndash Marin tremor rating scale (TRS), stimulation parameters, and the location of active contacts were compared between patients classified as ET and ET-p. TRS scores at baseline were higher in ET-p. ET-p patients showed comparable tremor reduction as patients with ET, albeit higher stimulation parameters were needed in ET-p. Active electrode contacts were located more dorsally in ET-p of uncertain reason. Our data show that DBS is similarly effective in ET-p compared to ET. TRS scores were higher in ET-p preoperatively, and higher stimulation parameters were needed for tremor reduction compared to ET. The latter may be related to a more dorsal location of active electrode contacts in the ET-p group of this cohort. Prospective studies are warranted to investigate DBS in ET-p further. |
| Databáze: | OpenAIRE |
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