Secondary Structures of Proteins Follow Menzerath-Altmann Law
| Autor: | Vladimír Matlach, Daniel Dostál, Marian Novotný |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Menzerath–Altmann law secondary structures proteins quantitative linguistics empirical law formula fitting QH301-705.5 Statistics as Topic Catalysis Protein Structure Secondary Inorganic Chemistry parasitic diseases Biology (General) Physical and Theoretical Chemistry Databases Protein QD1-999 Molecular Biology Spectroscopy Organic Chemistry Proteins General Medicine Computer Science Applications Chemistry lipids (amino acids peptides and proteins) Algorithms Subcellular Fractions |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1569 International Journal of Molecular Sciences, Vol 23, Iss 1569, p 1569 (2022) |
| ISSN: | 1422-0067 |
| Popis: | This article examines the presence of the empirical tendency known as the Menzerath–Altmann Law (MAL) on protein secondary structures. MAL is related to optimization principles observed in natural languages and in genetic information on chromosomes or protein domains. The presence of MAL is examined on a non-redundant dataset of 4728 proteins by verifying significant, negative correlations and testing classical and newly proposed formulas by fitting the observed trend. We conclude that the lengths of secondary structures are specifically dependent on their number inside the protein sequence, while possibly reflecting the formula proposed in this paper. This behavior is observed on average but is individually avoidable and possibly driven by a latent cost function. The data suggest that MAL could provide a useful guiding principle in protein design. |
| Databáze: | OpenAIRE |
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