ON the Passage of an Exogenous Diamine Oxidase Inhibitor to the Amniotic Fluid
| Autor: | Fredrik Jonassen, Anne-Marie Fredholm, Åke Törnqvist, G. Samsioe |
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| Rok vydání: | 1973 |
| Předmět: |
Time Factors
Amniotic fluid Guanidines Injections Intramuscular Andrology Pregnancy Humans Medicine chemistry.chemical_classification business.industry Diamine oxidase activity Obstetrics and Gynecology Venous Plasma General Medicine Amniotic Fluid Thin-layer chromatography Enzyme Biochemistry chemistry Depression Chemical Amniocentesis Gestation Female Indicators and Reagents Amine Oxidase (Copper-Containing) Chromatography Thin Layer Diamine oxidase Intramuscular injection business |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 52:25-28 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.3109/00016347309158485 |
| Popis: | In a previous study on diamine oxidase activity of amniotic fluid (4) it was questioned whether enzyme inhibition with an intramuscular injection of aminoguanidine sulphate was due to a passage of the inhibitor to the amniotic fluid or was secondary to enzyme inhibition in the maternal blood. In the present investigation amniotic fluid was sampled from 23 women in the second trimester of gestation. In 15 cases, aminoguanidine sulphate was given 1 hour before sampling. In 5 cases aminoguanidine sulphate was detected in the amniotic fluid by thin layer chromatography and a subsequent staining technique. In 10 cases the presence of a diamine oxidase inhibitor in the amniotic fluid was shown by observing the effect of this amniotic fluid on venous plasma with a high diamine oxidase activity. When aminoguanidine sulphate was not given, the amniotic fluid did not show such inhibitory effects. Nor did the incubation itself inhibit the enzyme. |
| Databáze: | OpenAIRE |
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